MECHANISM OF ANTIINFLAMMATORY ACTIONS OF CURCUMINE AND BOSWELLIC ACIDS
MECHANISM OF ANTIINFLAMMATORY ACTIONS OF CURCUMINE AND BOSWELLIC ACIDS
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DOI：
10.1016/0378-8741(93)90005-p
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发表时间：
1993-03-01
影响因子：
5.4
通讯作者：
SABIERAJ, J
中科院分区：
文献类型：
--
作者：
AMMON, HPT;SAFAYHI, H;SABIERAJ, J
本研究以姜黄素和乳香树脂为主要成分，通过体外实验研究其抗炎作用机制。姜黄素能抑制大鼠腹腔中性粒细胞5-脂氧合酶活性和人血小板12-脂氧合酶及环氧合酶活性。在无细胞过氧化体系中，姜黄素具有较强的抗氧化活性。因此，其对双加氧酶的影响可能是由于其还原能力。乳香酸是从乳香树胶中分离得到的有效成分。乳香酸抑制5-脂氧合酶合成白三烯，但不影响12-脂氧合酶和环氧合酶的活性。此外，乳香酸没有损害花生四烯酸的铁和抗坏血酸的过氧化作用。这些数据表明，乳香酸是特定的，非氧化还原抑制剂的白三烯合成直接与5-脂氧合酶或阻断其易位。
Curcumine from Curcuma longa and the gum resin of Boswellia serrata, which were demonstrated to act as antiinflammatories in in vivo animal models, were studied in a set of in vitro experiments in order to elucidate the mechanism of their beneficial effects. Currumine inhibited the 5-lipoxygenase activity in rat peritoneal neutrophils as well as the 12-lipoxygenase and the cyclooxygena activities in human platelets. In a cell free peroxidation system curcumine exerted strong antioxidative activity. Thus, its effects on the dioxygenases are probably due to its reducing capacity. Boswellic acids were isolated from the gum resin of Boswellia serrata and identified as the active principles. Boswellic acids inhibited the leukotriene synthesis via 5-lipoxygenase, but did not affect the 12-lipoxygenase and the cyclooxygenase activities. Additionally, boswellic acids did not impair the peroxidation of arachidonic acid by iron and ascorbate. The data suggest that boswellic acids are specific, non-redox inhibitors of leukotriene synthesis either interacting directly with 5-lipoxygenase or blocking its translocation.