Endocrine Disruptors: A Potential Risk Factor for Gestational Diabetes Mellitus
Endocrine Disruptors: A Potential Risk Factor for Gestational Diabetes Mellitus
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DOI：
10.1055/s-0036-1586500
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发表时间：
2016-11-01
影响因子：
2
通讯作者：
Ho, Shuk-Mei
中科院分区：
文献类型：
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作者：
Ehrlich, Shelley;Lambers, Donna;Ho, Shuk-Mei
在过去的20年里，随着肥胖症的流行，妊娠期糖尿病（GDM）急剧增加。GDM发病率的增加反映了内分泌干扰物（EDCs）的使用增加。内分泌干扰物在结构上类似于内源性激素，干扰天然激素的合成、分泌、活性或消除，导致不良健康影响，包括糖尿病、肥胖、发育障碍等。尽管双酚A（BPA）（一种研究充分的EDC）与2型糖尿病之间的关联已在流行病学和动物研究中反复研究，但是缺乏对内分泌干扰物和妊娠期糖尿病的研究。事实上，环境毒素对围产期健康结果的影响在很大程度上被忽视了。认识到这一研究空白，美国妇产科医师学会、美国生殖医学会和国际妇产科联合会最近加入了领先的科学家和临床医生的行列，呼吁采取行动，优先研究暴露于有毒环境因子对妇女健康的影响。有证据表明信号分子和内分泌干扰物参与了滋养层细胞microRNA（miRNA）表达的调控。我们回顾了现有的科学证据，内分泌干扰物作为GDM的危险因素，以及miRNA在这种关联中的潜在作用。
Gestational diabetes mellitus (GDM) has increased dramatically in the past 20 years together with the obesity epidemic. Mirroring the increase in incidence of GDM is increasing use of endocrine disrupting chemicals (EDCs). EDCs are structurally similar to endogenous hormones and interfere with synthesis, secretion, activity, or elimination of natural hormones, resulting in adverse health effects, including diabetes, obesity, developmental disorders, etc. Although the association between bisphenol A (BPA), a well-studied EDC, and type 2 diabetes has been repeatedly investigated in epidemiological and animal studies, there is a dearth of studies examining EDCs and GDM. In fact, the impact of environmental toxins on perinatal health outcomes has largely been overlooked.Recognizing this research gap, the American College of Obstetricians and Gynecologists, American Society for Reproductive Medicine, and International Federation of Gynecology and Obstetrics recently joined leading scientists and clinicians in a call for action to prioritize research in the consequences of exposure to toxic environmental agents on women's health. Evidence is emerging to suggest signaling molecules and EDCs are involved in the control of microRNA (miRNA) expression in trophoblast cells. We reviewed existing scientific evidence of EDCs as a risk factor for GDM as well as the potential role of miRNA in this association.