Phase-amplitude cross-frequency coupling in the human nucleus accumbens tracks action monitoring during cognitive control
Phase-amplitude cross-frequency coupling in the human nucleus accumbens tracks action monitoring during cognitive control
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DOI：
10.3389/fnhum.2013.00635
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发表时间：
2013-10-07
影响因子：
2.9
通讯作者：
Hinrichs, Hermann
中科院分区：
文献类型：
--
作者：
Duerschmid, Stefan;Zaehle, Tino;Hinrichs, Hermann
伏隔核（Nucleus Accumbens, NAcc）是皮层和皮层下结构，特别是前额皮质和海马之间信息传递的重要结构。然而，允许NAcc实现这种整合的机制尚不清楚。不同频段振荡的相幅交叉频耦合（PAC）被认为是形成功能网络以优化信息传递和集成的有效机制。在这里，我们评估了theta和高gamma振荡之间的PAC作为促进运动适应的潜在机制。为了解决这个问题，我们直接记录了三名患者在执行运动学习任务时双侧人类NAcc的颅内场电位，这些任务在执行任务所需的认知控制水平上有所不同。与啮齿类动物一样，PAC在人类NAcc中也可以观察到，在运动反应后短暂地发生在运动的对侧。重要的是，PAC与监控所执行动作所需的认知控制水平相关。这种功能关系表明，NAcc参与动作监测，并通过PAC支持适应性行为中运动程序的评估。
The Nucleus Accumbens (NAcc) is an important structure for the transfer of information between cortical and subcortical structures, especially the prefrontal cortex and the hippocampus. However, the mechanism that allows the NAcc to achieve this integration is not well understood. Phase-amplitude cross-frequency coupling (PAC) of oscillations in different frequency bands has been proposed as an effective mechanism to form functional networks to optimize transfer and integration of information. Here we assess PAC between theta and high gamma oscillations as a potential mechanism that facilitates motor adaptation. To address this issue we recorded intracranial field potentials directly from the bilateral human NAcc in three patients while they performed a motor learning task that varied in the level of cognitive control needed to perform the task. As in rodents, PAC was observable in the human NAcc, transiently occuring contralateral to a movement following the motor response. Importantly, PAC correlated with the level of cognitive control needed to monitor the action performed. This functional relation indicates that the NAcc is engaged in action monitoring and supports the evaluation of motor programs during adaptive behaviour by means of PAC.