MicroRNA control of lifespan and metabolism
MicroRNA control of lifespan and metabolism
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DOI：
10.4161/cc.5.8.2688
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发表时间：
2006-04-15
期刊：
影响因子：
4.3
通讯作者：
Slack, Frank J.
中科院分区：
文献类型：
--
作者：
Boehm, Michelle;Slack, Frank J.
一个小的非编码RNA家族，称为microRNA，最近出现了基因表达的序列特异性调节因子。在几乎所有的后生动物基因组中已经鉴定出数百种microRNA，但它们才刚刚开始按功能作用进行分类。在这里，我们回顾了已被证明在两个密切相关的过程中发挥作用的microRNA，寿命和代谢调节。了解这些新基因调控因子的代谢和寿命调控作用无疑将进一步加深我们对控制寿命和代谢的复杂遗传网络的理解，也将为我们提供代谢和年龄相关疾病的神经干预的新靶点。
A family of small, noncoding RNAs, known as microRNAs, has recently emerged as sequence-specific regulators of gene expression. Hundreds of microRNAs have been identified in almost all metazoans genomes, but they are only beginning to be classified by functional roles. Here, we review microRNAs that have been shown to play roles in two closely related processes, lifespan and metabolic regulation. Understanding the metabolic and lifespan regulatory roles of these novel gene regulators will undoubtedly further our understanding of the complex genetic networks that control lifespan and metabolism, and will also provide us with novel targets for the theurapeutic intervention of metabolic and age-related diseases.