Trends in the rates of resistance of Ureaplasma urealyticum to antibiotics and identification of the mutation site in the quinolone resistance-determining region in Chinese patients
Trends in the rates of resistance of Ureaplasma urealyticum to antibiotics and identification of the mutation site in the quinolone resistance-determining region in Chinese patients
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DOI：
10.1111/j.1574-6968.2006.00239.x
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发表时间：
2006-06-01
影响因子：
2.1
通讯作者：
Zhang, Jun
中科院分区：
文献类型：
--
作者：
Xie, Xinyou;Zhang, Jun
对连续六年（1999-2004）3月至6月从中国杭州邵逸夫医院门诊的804名患者分离出的解脲支原体对抗菌药物的耐药性进行了审查。对六株解脲脲原体的喹诺酮耐药决定区进行了分析。对多西环素、交沙霉素、四环素、阿奇霉素、克拉霉素和普那霉素的耐药率低于20%，并且在研究期间没有变化。对氟喹诺酮类药物（氧氟沙星、环丙沙星）的耐药率远高于这些药物（>50%），并且自1999年以来一直在增加。对红霉素的耐药率从1999年的63.9%下降到2000年以后的20%左右。氟喹诺酮类药物的广泛使用导致解脲支原体耐药率较高，并出现了喹诺酮类药物耐药性。对拓扑异构酶 IV 和 DNA 旋转酶基因序列的分析表明，拓扑异构酶 IV ParE 亚基在氟喹诺酮耐药解脲支原体中发挥着作用。
The resistance of Ureaplasma urealyticum to antibacterials, isolated from 804 patients from the outpatient clinic of the Sir Run Run Shaw Hospital Hangzhou, China, from March to June over six consecutive years (1999-2004) was reviewed. The quinolone resistance-determining region of six strains of U. urealyticum was analyzed. The level of resistance to doxycycline, josamycin, tetracycline, azithromycin, clarythromycin and pristinamycin was below 20% and did not change during the study period. The rate of resistance to fluoroquinolones (ofloxacin, ciprofloxacin) was much greater than these (> 50%) and has increased since 1999. The rate of resistance to Erythromycin decreased from 63.9% in 1999 to about 20% from 2000 onwards. The widespread use of fluoroquinolones had led to high resistance rates in U. urealyticum and the emergence of quinolone resistance. Analysis of the gene sequence of topoisomerase IV and DNA gyrase suggested a role for the topoisomerase IV ParE subunit in fluoroquinolone-resistant U. urealyticum.