Genomic signatures of influenza A pandemic (H1N1) 2009 virus.
Genomic signatures of influenza A pandemic (H1N1) 2009 virus.
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DOI：
10.3201/eid1512.090845
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发表时间：
2009-12
影响因子：
11.8
通讯作者：
Shih SR
中科院分区：
文献类型：
--
作者：
Chen GW;Shih SR
宿主物种特定位置的氨基酸特征可能会影响病毒转化。导致 2009 年甲型流感大流行 (H1N1) 病毒出现的适应性突变仍然未知，该病毒可以在人类中复制和传播。我们对流感蛋白序列进行了大规模扫描，并确定了宿主物种特有的氨基酸保守位置，称为特征。在通过非糖蛋白区分禽类病毒和人类病毒的 47 个特征中，有 8 个与 2009 年 H1N1 流感大流行病毒相似。仔细检查2009年H1N1大流行病毒的最新猪源病毒中的氨基酸残基发现，其中7个已经转变为类似人类的残基，只有PA 356保留了类似禽类的K；在 2009 年 H1N1 流感大流行病毒中，该残基变成了类似人类的 R。还存在区分猪病毒和人类病毒的特征。对非人类物种的这些特征进行持续监测将有助于流感监测和评估进一步适应人类的可能性。
Amino acid signatures at host species–specific positions may affect virus transformation. Adaptive mutations that have contributed to the emergence of influenza A pandemic (H1N1) 2009 virus, which can replicate and transmit among humans, remain unknown. We conducted a large-scale scanning of influenza protein sequences and identified amino acid–conserving positions that are specific to host species, called signatures. Of 47 signatures that separate avian viruses from human viruses by their nonglycoproteins, 8 were human-like in the pandemic (H1N1) 2009 virus. Close examination of their amino acid residues in the recent ancestral swine viruses of pandemic (H1N1) 2009 virus showed that 7 had already transitioned to human-like residues and only PA 356 retained an avian-like K; in pandemic (H1N1) 2009 virus, this residue changed into a human-like R. Signatures that separate swine viruses from human viruses were also present. Continuous monitoring of these signatures in nonhuman species will help with influenza surveillance and with evaluation of the likelihood of further adaptation to humans.
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