Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10
Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10
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DOI：
10.1093/infdis/jiw147
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发表时间：
2016-07-15
影响因子：
6.4
通讯作者：
Feeney, Margaret E.
中科院分区：
文献类型：
--
作者：
Jagannathan, Prasanna;Bowen, Katherine;Feeney, Margaret E.
背景资料。对活的恶性疟原虫子孢子进行实验性接种，并针对血液期寄生虫进行化学预防，可产生保护性免疫。目前尚不清楚在自然暴露于疟疾后，化学预防是否同样提高了免疫力。方法：研究方法。我们评估了乌干达儿童中恶性疟原虫特异性T细胞的反应，这些儿童被随机分配到6-24个月大的儿童中，每月接受双氢青蒿素-哌喹(DP；n=87)或不接受化学预防(n=90)，并进行依从性的药理学评估，然后再临床随访一年。结果。在干预期间，每个月的疟疾发病率总体减少了55%(P
Background. Experimental inoculation of viable Plasmodium falciparum sporozoites administered with chemoprevention targeting blood-stage parasites results in protective immunity. It is unclear whether chemoprevention similarly enhances immunity following natural exposure to malaria. Methods. We assessed P. falciparum-specific T-cell responses among Ugandan children who were randomly assigned to receive monthly dihydroartemisinin-piperaquine ( DP; n = 87) or no chemoprevention ( n = 90) from 6 to 24 months of age, with pharmacologic assessments for adherence, and then clinically followed for an additional year. Results. During the intervention, monthly DP reduced malaria episodes by 55% overall ( P