High expression of neuropeptide Y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia
High expression of neuropeptide Y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia
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DOI：
10.1158/1078-0432.ccr-04-0821
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发表时间：
2004-12-15
影响因子：
11.5
通讯作者：
Reubi, JC
中科院分区：
文献类型：
--
作者：
Körner, M;Waser, B;Reubi, JC
用途：最近，神经肽Y（NPY）在肿瘤生物学中的作用，提出了基于在乳腺癌和卵巢癌中的高密度的NPY受体。NPY受体在产生类固醇激素的卵巢性索间质肿瘤中的高频率，连同已知的NPY对啮齿动物肾上腺中类固醇激素和儿茶酚胺分泌的影响，导致对人肾上腺和相关肿瘤中NPY受体表达的研究。15例肾上腺皮质肿瘤，20例副神经节瘤，23例嗜铬细胞瘤，20例神经母细胞瘤，用~（125）I标记的离体NPY受体放射自显影技术，对10例正常肾上腺和8例正常肾上腺进行了研究。结果：93%的皮质肿瘤表达Y1，35%的嗜铬细胞瘤和61%的副神经节瘤表达Y1和Y2，90%的神经母细胞瘤表达Y2受体。嗜铬细胞瘤、副神经节瘤和神经母细胞瘤中的NPY受体通常与化学检测到的NPY激素同时表达。肾上腺皮质强烈表达Y1，而没有NPY受体被发现在adrenalmedula.Conclusions：这些受体的数据表明，在肾上腺皮质肿瘤的作用，以及强大的NPY神经支配的皮质，生理作用在肾上腺，介导的Y1受体。这些神经肽Y受体是一个潜在的恶性肿瘤治疗的新分子靶点。
Purpose: Recently, a role of neuropeptide Y (NPY) in tumor biology was suggested based on the high density of NPY receptors in breast and ovarian cancers. The high frequency of NPY receptors in steroid hormone-producing ovarian sex cord-stromal tumors, together with the known influence of NPY on steroid hormone and catecholamine secretion in the rodent adrenal gland, led to the investigation of NPY receptor expression in the human adrenal gland and related tumors.Experimental Design: Fifteen adrenal cortical tumors, 20 paragangliomas, 23 pheochromocytomas, 20 neuroblastomas, and 8 normal adrenal glands were investigated by in vitro NPY receptor autoradiography using I-125-labeled peptide YY in competition experiments with receptor subtype selective analogs.Results: Ninety three percent of cortical tumors express Y1, 35% of pheochromocytomas and 61% of paragangliomas express Y1 and Y2, and 90% of neuroblastomas express Y2 receptors. The NPY receptors in pheochromocytomas, paragangliomas, and neuroblastomas are often expressed concomitantly with the NPY hormone detected immunohistochemically. The adrenal cortex strongly expresses Y1, whereas no NPY receptors are found in the adrenal medulla.Conclusions: These receptor data suggest a role of NPY in adrenal cortical tumors and, together with the strong NPY innervation of the cortex, a physiologic role in the adrenal gland, mediated by Y1 receptors. These NPY receptors are a potential new molecular target for the therapy of malignant tumors.