Functional connectivity between anterior cingulate cortex and orbitofrontal cortex during value-based decision making
Functional connectivity between anterior cingulate cortex and orbitofrontal cortex during value-based decision making
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DOI：
10.1016/j.nlm.2017.11.014
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发表时间：
2018-01-01
影响因子：
2.7
通讯作者：
Kermani, Mojtaba
中科院分区：
文献类型：
--
作者：
Fatahi, Zahra;Haghparast, Abbas;Kermani, Mojtaba
越来越多的证据表明，前扣带回（ACC）和眶额（OFC）皮质都是至关重要的决策指导。聚焦于通过连贯性的功能连接方法，我们研究了ACC和OFC之间通过神经同步的通信是否是执行基于价值的决策的必要阶段。我们使用了一个T-迷宫任务与差异奖励（大与小奖励）和成本（长与短的等待时间），并同时记录了本地场电位（LFP）从ACC和OFC。当大鼠选择更高的奖励而不是更低的奖励时，在θ/低β（4-20 Hz）频带之间观察到任务依赖性同步。当大鼠选择较低的奖励或被动地执行任务时，这种同步性明显较差。还观察到区域之间的高伽马（80-100 Hz）同步，然而，它不依赖于动物的决定。我们的研究结果表明，在低频范围内的ACC和OFC之间的同步是必要的基于价值的决策。
There is a growing body of evidence showing that the anterior cingulate (ACC) and the orbitofrontal (OFC) cortex are both essential for reinforcement-guided decision making. Focusing on functional connectivity approach through coherence, we studied whether communication between the ACC and OFC through neural synchronization is a necessary stage for performing value-based decision making. We used a T-maze task with a differential reward (Large vs. small reward) and cost (long vs. short waiting time) and simultaneously recorded local field potentials (LFP) from the ACC and OFC. Task-dependent synchronization in theta/low beta (4-20 Hz) frequency bands were observed between areas when rats chose the higher over the lower reward. This synchronization was significantly poorer when rats chose lower rewards or passively performed the task. High gamma (80-100 Hz) synchrony between areas was also observed, however, it was not dependent on the animal's decision. Our results propose that synchronization between the ACC and OFC in the low-frequency range is necessary during value-based decision making.