Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys
Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys
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DOI：
10.1016/j.vaccine.2008.09.022
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发表时间：
2008-11-25
期刊：
影响因子：
5.5
通讯作者：
De Jong, Mart C. M.
中科院分区：
文献类型：
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作者：
Bos, Marian E. H.;Nielen, Mirjam;De Jong, Mart C. M.
本研究描述了高致病性禽流感（HPAI）H7 N7病毒在12周龄火鸡中的传播实验结果。采集泄殖腔和气管拭子以及血清样本，以监测接种和易感接触火鸡的感染情况，这些火鸡均未接种H7 N1疫苗，接种一次或接种两次。拭子采用实时荧光定量PCR检测，血清标本采用血凝抑制试验（HI）检测。未接种疫苗的接触禽的平均感染期为6.2天，估计传播率参数为1.26/感染禽/天。然而，在接种疫苗的火鸡中没有发现病毒脱落，因此我们得出结论，用H7 N1疫苗接种可以保护免受HPAI H7 N7病毒的攻击。(c)2008爱思唯尔有限公司保留所有权利。
This study describes the results of a transmission experiment with highly pathogenic avian influenza (HPAI) H7N7 virus in 12-week-old turkeys. Cloacal and tracheal swabs as well as serum samples were taken to monitor the infection both in inoculated and in susceptible contact turkeys, which were all either unvaccinated, vaccinated once or vaccinated twice with H7N1. Swabs were tested by real-time RT-PCR and serum samples with hemagglutination inhibition test (HI). Unvaccinated contact birds had a mean infectious period of 6.2 days, and an estimated transmission rate parameter of 1.26 per infectious bird per day. However, no virus shedding was found in inoculated vaccinated turkeys and thus we concluded that vaccination with H7N1 protected against challenge with HPAI H7N7 virus. (c) 2008 Elsevier Ltd. All rights reserved.