Bronchodilator responsiveness testing using raised volume forced expiration in recurrently wheezing infants
Bronchodilator responsiveness testing using raised volume forced expiration in recurrently wheezing infants
复制标题
使用增加的容量强制呼气对反复喘息的婴儿进行支气管扩张剂反应性测试
作者：
M. Hayden;J. Wildhaber;P. Lesouëf
We hypothesized that a new test of infant lung function, less affected by shifts in lung volume, might better detect bronchodilator effects. Using the raised volume forced expiration technique (RVFET), the effect of a bronchodilator on lung function was studied in 22 infants with a history of recurrent wheeze and five healthy infants. Forced expiratory volume in 0.75 s (FEV0.75), forced expiratory vital capacity (FVC), and forced expiratory flow at 75% of FVC (FEF75%) were measured by forcing expiration, using an inflatable jacket from a lung volume set by an inspiratory pressure of 20 cm H2O. A minimum of five measurements were made at baseline and following the administration of 500 μg of salbutamol from a metered dose inhaler via a small volume metal spacer. Changes in lung function in the group of 25 infants who received salbutamol were compared to seven infants who received placebo aerosol.
婴儿气道反应性：对乙酰甲胆碱和异丙肾上腺素呈阳性反应。
DOI：
10.1152/jappl.1987.62.3.1155
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Tepper,RS
通讯作者：
Tepper,RS
DOI：
10.1152/jappl.1987.62.3.1117
发表时间：
1987
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Stark,AR;Cohlan,BA;Waggener,TB;Frantz3rd,ID;Kosch,PC
通讯作者：
Kosch,PC
影响因子：
158.5
作者：
MARTINEZ, FD;WRIGHT, AL;MCLELLAN, M
通讯作者：
MCLELLAN, M