Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue
Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue
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DOI：
10.1016/j.neures.2020.04.005
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发表时间：
2021-03-19
影响因子：
2.9
通讯作者：
Cui, Yilong
中科院分区：
文献类型：
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作者：
Li, Danxi;Hu, Di;Cui, Yilong
慢性疲劳综合征（CFS）的特征是长期疲劳和一系列症状，并涉及体内平衡破坏。CFS患者即使在正常体温下也经常主诉低热或寒战，表明CFS患者的热感觉或体温调节功能可能受到干扰。然而，人们对详细的机制知之甚少。为了阐明在慢性疲劳的发展过程中体温调节功能是否以及如何改变，我们使用无线应答器在慢性疲劳大鼠模型中研究了体温随疲劳累积的时间变化。我们的研究结果表明，体温适应性增加响应疲劳负荷在早期阶段，但不能保持在后期阶段。尾部散热现象较为常见，且尾部散热频率先增加后减少。在疲劳加载后期，尾部散热阶段的体温下降到低于非散热阶段的体温。这些结果表明，随着疲劳的进展，体温调节功能发生了适应性变化，但该系统可能会被长期疲劳破坏，这可能是疲劳慢性化机制的基础。(C)2020 Elsevier B.V.和日本神经科学学会。All rights reserved.
Chronic fatigue syndrome (CFS) is characterized by long-lasting fatigue, and a range of symptoms, and is involved in homeostasis disruption. CFS patients frequently complain of low grade fever or chill even under normal body temperature indicating that thermosensory or thermoregulatory functions might be disturbed in CFS. However, little is known about the detailed mechanisms. To elucidate whether and how thermoregulatory function was altered during the development of chronic fatigue, we investigated temporal changes in body temperature with advance of fatigue accumulation in a chronic fatigue rat model using a wireless transponder. Our findings demonstrated that the body temperature was adaptively increased in response to fatigue loading in the early phase, but unable to retain in the late phase. The tail heat dissipation was often observed and the frequency of tail heat dissipation gradually increased initially, then decreased. In the late phase of fatigue loading, the body temperature for the tail heat dissipation phase decreased to a value lower than that for the non-dissipation phase. These results suggest that adaptive changes in thermoregulatory function occurred with fatigue progression, but this system might be disrupted by long-lasting fatigue, which may underlie the mechanism of fatigue chronification. (C) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.