Downregulation of serum long noncoding RNA GAS5 may contribute to insulin resistance in PCOS patients
Downregulation of serum long noncoding RNA GAS5 may contribute to insulin resistance in PCOS patients
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血清长非编码RNA GAS5的下调可能导致PCOS患者的胰岛素抵抗
DOI：
10.1080/09513590.2018.1459548
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发表时间：
2018-01-01
影响因子：
2
通讯作者：
Zhang, Qingxue
中科院分区：
文献类型：
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作者：
Lin, Haiyan;Xing, Weijie;Zhang, Qingxue
多囊卵巢综合征（PCOS）是一种常见于育龄妇女的内分泌疾病，以胰岛素抵抗（IR）为主要特征。其潜在机制尚不清楚。长链非编码rna （lncRNAs）已被证明参与细胞发育、代谢和分化的各种水平的生物学调控过程。本研究旨在探讨IR与PCOS患者血清中lncRNA Growth-arrest specific transcript 5 （GAS5）差异表达的关系。收集非PCOS、PCOS伴IR及不伴IR患者血清76例，检测与IR相关的白细胞介素-18 （IL-18）和GAS5的表达。PCOS合并IR患者血清IL-18浓度显著升高。PCOS合并IR患者血清中GAS5表达降低。相关分析结果显示，GAS5表达与胰岛素抵抗稳态评估模型（HOMA-IR）呈负相关。GAS5为ROC曲线（AUC）。我们的研究表明，血清中IL-18的表达升高和GAS5的下调可能与PCOS患者的IR有关。
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disease that affects reproductive-aged women and mostly characterized by insulin resistance (IR). The underlying mechanism remains unknown. Long noncoding RNAs (lncRNAs) have been demonstrated to be involved in various levels of biological regulation process of cell development, metabolism, and differentiation. This study aims to investigate the relationship between IR and differential expression of lncRNA Growth-arrest specific transcript 5 (GAS5) in patients’ serum with and without PCOS. A total of 76 cases of serum was collected from non-PCOS and PCOS patients with and without IR to measure interleukin-18 (IL-18) and GAS5 expression, which were correlated with IR status. The IL-18 concentration in serums was significantly increased in PCOS patients with IR. GAS5 expression was decreased in serums in PCOS patients with IR. Result of correlation analysis shows that there is a negative association between GAS5 expression and homeostasis model of assessment for insulin resistance (HOMA-IR). GAS5 was yielded the ROC curve (AUC). Our study implied that elevated IL-18 expression and downregulation of GAS5 in serums might contribute to IR in PCOS patients.