Clinical conditions associated with PCP in children
Clinical conditions associated with PCP in children
复制标题
DOI：
10.1002/ppul.21577
复制
发表时间：
2012-05-01
影响因子：
3.1
通讯作者：
Sullivan, Kathleen E.
中科院分区：
文献类型：
--
作者：
Saltzman, Rushani W.;Albin, Stephanie;Sullivan, Kathleen E.
耶氏肺孢子菌是免疫受损者中机会性感染的主要原因。 20世纪80年代，人们的注意力集中在艾滋病毒患者身上，然而，随着抗逆转录病毒治疗的出现，我们希望重新审视儿童肺孢子菌肺炎相关的基础疾病问题。我们确定了 1986 年至 2006 年期间的 80 例病例，并进行了回顾性图表审查，以确定每个病例的临床特征。 HIV是该队列中最常见的相关基础疾病，占总体病例的39%，但自1998年以来，仅占病例的15%。移植受者和肿瘤患者总共占病例的39%，其中9%的病例归因于原发性免疫缺陷，另外9%的病例与不太被充分认识的易感性原因相关。这项研究证明，在不太被充分认识的临床情况下，诊断肺孢子菌肺炎时需要保持警惕。小儿肺科。 2012年； 47:510516。 (c) 2011 年 Wiley 期刊公司。
Pneumocystis jirovecii is a leading cause of opportunistic infections among the immune compromised. During the 1980s, attention focused on patients with HIV, however, with the advent of anti-retroviral therapy, we wished to revisit the question of underlying diseases associated with Pneumocystis pneumonia in children. We identified 80 cases from 1986 to 2006 and performed a retrospective chart review to identify clinical characteristics for each of the cases. HIV was the single most common associated underlying condition seen in this cohort, accounting for 39% of the cases overall, however, it was seen in just 15% of the cases since 1998. Transplant recipients and oncology patients together comprised another 39% of the cases, with 9% of cases attributed to primary immune deficiency and another 9% of cases associated with less well-recognized causes of susceptibility. This study documents the ongoing need for vigilance to diagnose Pneumocystis pneumonia in less well-recognized clinical scenarios. Pediatr Pulmonol. 2012; 47:510516. (c) 2011 Wiley Periodicals, Inc.