Relationship between proliferative activity of tumor cells and the enlargement pattern of metastatic lymph nodes in oral squamous cell carcinomas
Relationship between proliferative activity of tumor cells and the enlargement pattern of metastatic lymph nodes in oral squamous cell carcinomas
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口腔鳞癌肿瘤细胞增殖活性与转移淋巴结肿大模式的关系
DOI：
10.1016/j.ajoms.2016.09.012
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Kenji Kawano
中科院分区：
文献类型：
--
作者：
Tatsuyuki Kono;Yoshihiro Takahashi;Lazuhiro Kawamura;NOriaki Yamamoto;Ayaka Abe;Kenji Kawano
目的：本研究旨在探讨口腔鳞状细胞癌（OSCC）转移淋巴结大小随时间的变化，并确定其与组织学特征的关系。方法：本研究检查了 13 例 OSCC 患者的 13 个转移淋巴结。定期对颈部淋巴结进行超声检查，三维测量中淋巴结最小轴（大小）≥8mm时诊断为转移性淋巴结。通过原发肿瘤和淋巴结的 Ki-67 免疫染色将转移淋巴结的肿大模式与肿瘤细胞的组织学特征和增殖活性进行比较。结果：转移淋巴结的肿大模式分为两种类型：快速肿大（RE），淋巴结大小快速增大；慢速肿大（SE），淋巴结大小缓慢增大且波动。在原发肿瘤或转移淋巴结中，RE 型和 SE 型之间的组织学结果没有观察到显着差异。另一方面，原发肿瘤和转移灶的Ki-67评分与转移淋巴结的肿大模式相关，其中RE型转移淋巴结的Ki-67评分显着高于SE型。结论：原发肿瘤的增殖活性可以作为预测转移淋巴结肿大速度的有价值的标志物。此外，它可能有助于就 N0 颈癌患者的随访持续时间做出决定。
Objectives: This study was conducted to investigate the time-course changes in the size of metastatic lymph nodes and determine their relationship with the histological features of oral squamous cell carcinomas (OSCC).Methods: Thirteen metastatic lymph nodes from 13 OSCC patients were examined in this study. The cervical lymph nodes were periodically followed up with ultrasonographic examination and diagnosed as metastatic when the minimum axis of the nodes (size) reached≥ 8 mm in three-dimensional measurements. Enlargement patterns of the metastatic nodes were compared with the histological features and proliferative activity of tumor cells by Ki-67 immunostaining of the primary tumors and nodes. Results: The enlargement patterns of the metastatic lymph nodes were classified into two types: rapid enlargement (RE), which involved rapid increase in node size, and slow enlargement (SE), which involved slow increase and fluctuation in size. No significant differences in histological findings between the RE and SE types were observed in the primary tumors or metastatic nodes. On the other hand, Ki-67 scores in primary tumors and metastatic foci were associated with the enlargement pattern of the metastatic nodes, wherein metastatic nodes of the RE type showed significantly higher Ki-67 scores than those of the SE type.Conclusions: The proliferative activity of primary tumors can be a valuable marker for predicting the speed of enlargement of metastatic lymph nodes. In addition, it may aid in reaching a decision regarding follow-up duration in N0 neck cancer patients.