Common exon duplication in animals and its role in alternative splicing
Common exon duplication in animals and its role in alternative splicing
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DOI：
10.1093/hmg/11.13.1561
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发表时间：
2002-06-15
影响因子：
3.5
通讯作者：
Bork, P
中科院分区：
文献类型：
--
作者：
Letunic, I;Copley, RR;Bork, P
当我们在人类、果蝇和蠕虫的基因组中寻找外显子重复的情况时，我们发现大约10%的基因含有串联重复的外显子。在分析的过程中，2438个未注释的外显子被鉴定出，这些外显子目前未被包括在基因组数据库中，并且可能是功能性的。它们中的绝大多数可能参与相互排斥的选择性剪接事件。最近的外显子重复的共同性质表明，它可能在真核生物基因的快速进化中发挥重要作用。它还提供了调节蛋白质功能的一般机制。
When searching the genomes of human, fly and worm for cases of exon duplication, we found that about 10% of all genes contain tandemly duplicated exons. In the course of the analyses, 2438 unannotated exons were identified that are not currently included in genome databases and that are likely to be functional. The vast majority of them are likely to be involved in mutually exclusive alternative splicing events. The common nature of recent exon duplication indicates that it might have a significant role in the fast evolution of eukaryotic genes. It also provides a general mechanism for the regulation of protein function.