Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of Corti: Intracochlear GDNF treatment reduces the number of apoptotic cells
Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of Corti: Intracochlear GDNF treatment reduces the number of apoptotic cells
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DOI：
10.1159/000027764
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发表时间：
2000-11-01
期刊：
影响因子：
--
通讯作者：
Ylikoski, J
中科院分区：
文献类型：
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作者：
Aarnisalo, AA;Pirvola, U;Ylikoski, J
我们研究了耳蜗神经退行性变后耳蜗核（CN）的形态和细胞变化，以及是否可以通过局部神经胶质细胞系衍生神经营养因子（GDNF）治疗挽救原代耳蜗神经元的退行性变来预防这些变化。经GDNF处理后，AVCN的体积明显大于未处理侧，且处理侧AVCN的细胞核大小明显大于未处理侧，螺旋神经节神经元变性后，同侧CN和上橄榄核复合体的凋亡细胞核数量增加。原代耳蜗神经元的变性似乎导致发生凋亡细胞死亡的CN神经元数量的增加，这可以通过局部GDNF治疗挽救原代耳蜗神经元免于变性来部分预防，版权(C) 2000 S. Karger AG, Basel。
We have studied the morphological and cellular changes in the cochlear nucleus (CN) after cochlear nerve degeneration and whether these changes can be prevented by rescuing the primary cochlear neurons from degeneration with local glial cell line derived neurotrophic factor (GDNF) treatment, Degeneration of spiral ganglion neurons was seen to lead to a reduction of the volume of the anteroventral cochlear nucleus (AVCN); the size of the cell nuclei in the AVCN also was reduced, No differences were observed in cell density, After intrascalar GDNF treatment the volume of the AVCN was significantly larger when compared to the untreated side, and the size of the cell nuclei in the AVCN was significantly larger on the treated side, After degeneration of spiral ganglion neurons, an increased number of apoptotic cell nuclei were seen in ipsilateral CN and superior olivary complex, This increase was significantly smaller after intrascalar GDNF treatment, Degeneration of primary cochlear neurons seems to lead to an increase in the number of CN neurons undergoing apoptotic cell death, This can be prevented partially by rescuing primary cochlear neurons from degeneration with local GDNF treatment, Copyright (C) 2000 S. Karger AG, Basel.