Social Dysfunctioning and Brain in Borderline Personality Disorder
Social Dysfunctioning and Brain in Borderline Personality Disorder
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DOI：
10.1159/000365106
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发表时间：
2014-01-01
期刊：
影响因子：
3.6
通讯作者：
Bertsch, Katja
中科院分区：
文献类型：
--
作者：
Herpertz, Sabine C.;Jeung, Haang;Bertsch, Katja
人际功能障碍是边缘型人格障碍（BPD）患者最突出、最具鉴别力的特征。来自实验精神病理学的数据表明，情绪不稳定、（自动）攻击、威胁超敏、人际修复机会差、经常误解和自我/他人扩散是导致BPD典型人际出轨的最重要因素。神经科学方法适合于阐明介导BPD社会功能缺陷的机制，即情感失调，冲动/去抑制和不良的社会认知以及它们的神经生物学相关因素。到目前为止，BPD患者的功能性神经影像学发现中最重要的是，前额叶杏仁核耦合低，抑制前额叶区的活性低，镜像神经元系统的活性高，心智化回路的活性低，以及违反社会规范时前岛叶的活性低。此外，面部情绪处理的特点已被检测的心理生理学方法在BPD患者。数据已经导致了BPD社会功能障碍的初步模型，这些模型必须在未来进行实验测试，将神经科学发展成为一种重要工具，以更好地了解BPD患者在与他人沟通时的痛苦。(C)2014 S. Karger AG，巴塞尔
Interpersonal dysfunction is the most prominent and best discriminating characteristic in individuals with borderline personality disorder (BPD). Data from experimental psychopathology point to emotional lability, (auto-) aggression, threat hypersensitivity, poor chance of interpersonal repair, frequent misunderstandings and self/other diffusion as the most significant factors which contribute to the interpersonal derailments typical of BPD. Neuroscientific methods are suitable to elucidate the mechanisms which mediate deficient social functioning in BPD, i.e. affective dysregulation, impulsivity/disinhibition and poor social cognition as well as their neurobiological correlates. Low prefrontoamygdalar coupling together with low activity in inhibiting prefrontal areas, high activity in the mirror neuron system, low activity in the mentalizing circuit, and low anterior insular activity in case of social norm violations are the most significant functional neuroimaging findings that have been reported from individuals with BPD, up to now. In addition, peculiarities of facial emotion processing have been detected by means of psychophysiological methodology in BPD patients. Data have led to preliminary models of social dysfunctioning in BPD that have to be experimentally tested in the future, evolving neuroscience into an important tool to better understand what distresses patients with BPD when communicating with others. (C) 2014 S. Karger AG, Basel