Spatial targeting of Screening + Eave tubes (SET), a house-based malaria control intervention, in Côte d'Ivoire: A geostatistical modelling study.
Spatial targeting of Screening + Eave tubes (SET), a house-based malaria control intervention, in Côte d'Ivoire: A geostatistical modelling study.
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筛选 +河水管的空间靶向（SET），一种基于房屋的疟疾控制干预措施，在科特迪瓦：一项地统计建模研究。
DOI：
10.1371/journal.pgph.0000030
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发表时间：
2021
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需要新的疟疾控制工具和因地制宜的干预措施，以减轻疟疾负担，实现全球目标。住房改造，筛查加上一个有针对性的基于房屋的杀虫剂输送系统，称为In 2Care ®屋檐管，已被证明可以减少临床疟疾在一个大的集群随机对照试验。然而，这种方法的微尺度适用性是未知的。我们的目标是预测家庭的适用性，并确定最合适的地点进行地面实况调查，在那里可以在科特迪瓦各地实施筛查+屋檐管（SET）。我们根据墙壁和屋顶材料将国土安全部抽样的家庭分为适合SET的家庭。我们使用集成嵌套拉普拉斯近似（INLA）拟合贝叶斯β-二项式逻辑模型，以预测SET的适用性，并确定地面实况调查的优先位置，并计算潜在的人口覆盖率和成本。根据现有的关于房屋类型和疟疾感染率的数据，总人口的31%和疟疾高传播地区人口的17.5%居住在适合理工科教育的地区。在合适的疟疾高传播地区实施SET的估计费用为4600万美元（1300万至1.08亿美元）。应该进行实地调查和更多的研究，以评估SET在这些环境中的有效性和可行性。这项研究提供了一个例子，说明如何执行反映当地社会经济和流行病因素的战略，而不是采取一刀切的战略。
New malaria control tools and tailoring interventions to local contexts are needed to reduce the malaria burden and meet global goals. The housing modification, screening plus a targeted house-based insecticide delivery system called the In2Care® Eave Tubes, has been shown to reduce clinical malaria in a large cluster randomised controlled trial. However, the widescale suitability of this approach is unknown. We aimed to predict household suitability and define the most appropriate locations for ground-truthing where Screening + Eave Tubes (SET) could be implemented across Côte d’Ivoire. We classified DHS sampled households into suitable for SET based on the walls and roof materials. We fitted a Bayesian beta-binomial logistic model using the integrated nested Laplace approximation (INLA) to predict suitability of SET and to define priority locations for ground-truthing and to calculate the potential population coverage and costs. Based on currently available data on house type and malaria infection rate, 31% of the total population and 17.5% of the population in areas of high malaria transmission live in areas suitable for SET. The estimated cost of implementing SET in suitable high malaria transmission areas would be $46m ($13m –$108m). Ground-truthing and more studies should be conducted to evaluate the efficacy and feasibility of SET in these settings. The study provides an example of implementing strategies to reflect local socio-economic and epidemiological factors, and move beyond blanket, one-size-fits-all strategies.