The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression.
The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression.
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DOI：
10.1155/2017/6138145
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发表时间：
2017
影响因子：
--
通讯作者：
Nagy B Jr
中科院分区：
文献类型：
--
作者：
Kappelmayer J;Nagy B Jr
在人类疾病的病理机制中，细胞相互作用是不可避免的。造血和非造血来源的不同细胞之间异型细胞聚集体的形成可能参与导致炎症和癌症进展的复杂过程的事件。在粘附受体中，选择素家族及其配体被认为是细胞-细胞相互作用的主要贡献者之一。因此，抑制选择素与其配体之间的相互作用可能具有潜在的治疗益处。在这篇综述中，我们集中在目前的证据选择素作为重要的调制器的炎症，血栓形成和恶性疾病。知道有混杂在选择素结合，我们概述了一个关键的蛋白质，作为所有选择素的配体的重要性。这种二聚体粘蛋白，P-选择素糖蛋白配体1（PSGL-1），已成为炎症，血栓和癌症发展的主要参与者。我们讨论了PSGL-1与各种选择素在生理和病理过程中的相互作用，特别强调导致严重疾病的机制。
Cellular interaction is inevitable in the pathomechanism of human disease. Formation of heterotypic cellular aggregates, between distinct cells of hematopoietic and nonhematopoietic origin, may be involved in events leading to inflammation and the complex process of cancer progression. Among adhesion receptors, the family of selectins with their ligands have been considered as one of the major contributors to cell-cell interactions. Consequently, the inhibition of the interplay between selectins and their ligands may have potential therapeutic benefits. In this review, we focus on the current evidence on the selectins as crucial modulators of inflammatory, thrombotic, and malignant disorders. Knowing that there is promiscuity in selectin binding, we outline the importance of a key protein that serves as a ligand for all selectins. This dimeric mucin, the P-selectin glycoprotein ligand 1 (PSGL-1), has emerged as a major player in inflammation, thrombus, and cancer development. We discuss the interaction of PSGL-1 with various selectins in physiological and pathological processes with particular emphasis on mechanisms that lead to severe disease.