Development of Distance-Selective Nerve Recruitment for Subcortical Brain Mapping by Controlling Stimulation Waveforms.
Development of Distance-Selective Nerve Recruitment for Subcortical Brain Mapping by Controlling Stimulation Waveforms.
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通过控制刺激波形开发用于皮质下脑测绘的距离选择性神经募集。
DOI：
10.1109/embc.2013.6609891
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Norihiro Katayama
中科院分区：
文献类型：
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作者：
Ayako Ueno;Akihiro Karashima;Mitsuyuki Nakao;Norihiro Katayama
在颅脑手术中，确定脑功能区和皮质-皮质通路，以保持其完整，保持患者的生活质量是非常重要的。皮层和皮层下脑映射是一种技术，它将直流电刺激传递到大脑表面和灰质下，以识别与高阶功能相关的大脑区域和神经纤维。然而，由于传统电刺激方法的非选择性作用，难以获得皮层下区域神经纤维的精确空间分布。我们研究了皮层下映射的电刺激来评估轴突到电极的距离选择性。澄清了传统的矩形双相脉冲非选择性地激活轴突。我们提出了双指数波形，并表明它们可以通过操纵刺激强度来招募目标纤维并改变目标的位置。这些结果表明，将距离选择性刺激引入皮质下脑制图是有用的。
During brain surgery, it is important to determine the functional brain area and cortico-cortical pathways so as to keep them intact and preserve patients' quality of life. Cortical and subcortical brain mappings are techniques that deliver direct current stimulation to the brain surface and beneath gray matter to identify the brain area and nerve fibers related to higher-order functions. However, because of the non-selective effect of conventional electrical stimulation methods, it has been difficult to obtain precise spatial distribution of nerve fibers in the subcortical region. We investigated the electrical stimulation of subcortical mapping to evaluate axon-to-electrode distance-selectivity. It was clarified that a conventional rectangular biphasic pulse activates axons non-selectively. We propose double exponential waveforms and show that they can recruit targeted fibers and change the location of a target by manipulating stimulus intensity. These results suggest the usefulness of introducing distance-selective stimulation into subcortical brain mapping.