Potential Role of the AMP-activated Protein Kinase in Regulation of Insulin Action.
Potential Role of the AMP-activated Protein Kinase in Regulation of Insulin Action.
复制标题
DOI：
--
复制
发表时间：
2006-01
期刊：
影响因子：
--
通讯作者：
J. Fisher
中科院分区：
文献类型：
--
作者：
J. Fisher
由于骨骼肌在胰岛素刺激的血糖清除中起主导作用，了解增强肌肉对胰岛素反应能力的机制可能会导致治疗或预防糖尿病的新策略。最近，AMP 激活蛋白激酶 (AMPK) 已成为增强胰岛素作用的有希望的候选者。几种抗糖尿病药物已被证明可以激活 AMPK，运动等细胞应激会增加 AMPK 活性，也会增加胰岛素作用，并且 AMPK 的几个下游靶标似乎参与胰岛素作用的调节。尽管目前情况还不完整，但 AMPK 或其效应器之一似乎有可能是胰岛素刺激的葡萄糖转运的正调节因子。除了讨论有关 AMPK 和胰岛素作用的最新文献外，本综述还为学生、其他领域的学者、感兴趣的专业人士和公众提供了非技术摘要。
Because of the predominant role of skeletal muscle in insulin-stimulated clearance of blood glucose, understanding mechanisms for increasing the ability of muscle to respond to insulin could potentially lead to novel strategies for treatment or prevention of diabetes. Recently, the AMP activated protein kinase (AMPK) has emerged as a promising candidate for potentiation of insulin action. Several antidiabetic drugs have been shown to activate AMPK, cellular stresses such as exercise that increase AMPK activity also increase insulin action, and several downstream targets of AMPK seem to be involved in regulation of insulin action. Although the picture is currently incomplete, it seems possible that AMPK or one of its effectors is a positive regulator of insulin-stimulated glucose transport. In addition to discussion of the latest literature regarding AMPK and insulin action, this review includes a non-technical summary for students, academics from other fields, interested professionals, and the general public.