METABOLIC-REGULATION IN MAMMALIAN SPERM - MITOCHONDRIAL VOLUME DETERMINES SPERM LENGTH AND FLAGELLAR BEAT FREQUENCY
METABOLIC-REGULATION IN MAMMALIAN SPERM - MITOCHONDRIAL VOLUME DETERMINES SPERM LENGTH AND FLAGELLAR BEAT FREQUENCY
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DOI：
10.1002/cm.970190306
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发表时间：
1991-01-01
影响因子：
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通讯作者：
BALTZ, JM
中科院分区：
文献类型：
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作者：
CARDULLO, RA;BALTZ, JM
在缺乏糖酵解支持的情况下，哺乳动物精子从鞭毛基部被称为中段的密集排列的线粒体获得运动能量。 利用200多种哺乳动物的形态测量数据，我们发现中段长度（L（m））和鞭毛长度（L（f））之间存在异速生长关系。 具体而言，中段的长度变化约为鞭毛长度的3/2的权力，虽然比例常数是不同的真兽目和有袋类精子。 与此相反，当我们校正了线粒体占据的中段部分时，发现所有哺乳动物的线粒体体积和鞭毛长度之间存在单一的线性相关性，这些异速生长关系与基本的鞭毛流体动力学理论一起沿着被用来建立一个统一的方程，预测长度在40 μ m和200 μ m之间的任何哺乳动物精子的鞭毛频率。 这些发现意味着，至少在哺乳动物中，精子鞭毛中能量产生和耗散的机制是高度保守的。
In the absence of glycolytic support, mammalian sperm derive their energy for motility from a densely packed array of mitochondria at the base of the flagellum known as the midpiece. Using data on the morphometric dimensions of over 200 mammalian species, we found that an allometric relationship exists between midpiece length (L(m)) and flagellum length (L(f)). Specifically, the length of the midpiece varies approximately as the 3/2 power of the flagellar length although the proportionality constant is different for eutherian and marsupial sperm. In contrast, when we corrected for the fraction of the midpiece that was taken up by mitochondria, a single linear correlation between mitochondrial volume and flagellar length for all mammals was found. These allometric relationships were used along with basic flagellar hydrodynamic theories to establish a unifying equation that predicted flagellar frequencies for any mammalian sperm between 40-mu-m and 200-mu-m in length. These findings imply that, at least in mammals, the mechanisms for energy production and dissipation in sperm flagella are highly conserved.