Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9).
Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9).
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DOI：
10.3390/jcm10215118
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发表时间：
2021-10-30
影响因子：
3.9
通讯作者：
Nakamura T
中科院分区：
文献类型：
--
作者：
Nakajima K;Igata M;Higuchi R;Tanaka K;Mizusawa K;Nakamura T
背景：尽管高密度脂蛋白具有心脏保护作用，但血清高密度脂蛋白胆固醇（HDL-C）与高血压之间的关系尚不清楚。因此，我们使用大型医疗数据集调查了高密度脂蛋白c浓度高低是否与高血压（HBP）相关。方法：在一项以社区为基础的横断研究中，对1,493,152名年龄在40-74岁之间接受健康检查的日本人（830,669名男性和662,483名女性）进行了调查，在医疗中心自动测量了9组HDL-C （20-110 mg/dL或以上）的血压。结果：在男性和女性中，9种HDL-C与血压呈粗略的u型关系。Logistic回归分析显示HDL-C与HBP（≥140/90 mmHg和/或药物治疗）的比值比呈左至右倒j型关系，男女的下限为90-99 mg/dL，在调整混杂因素后没有变化。然而，进一步调整体重指数和血清甘油三酯浓度显示HDL-C和HBP之间呈正线性关联，尽管在非酒精饮用者中仍然存在明显的u形关联。结论：低和极高HDL-C浓度与HBP相关。前者的关联可能依赖于伴随低HDL-C的过量脂肪量，而后者的关联可能主要依赖于频繁饮酒。
Background: although high-density lipoprotein has cardioprotective effects, the association between serum high-density lipoprotein cholesterol (HDL-C) and hypertension is poorly understood. Therefore, we investigated whether high and low concentrations of HDL-C are associated with high blood pressure (HBP) using a large healthcare dataset. Methods: in a community-based cross-sectional study of 1,493,152 Japanese people (830,669 men and 662,483 women) aged 40–74 years who underwent a health checkup, blood pressures automatically measured at healthcare center were investigated in nine HDL-C groups (20–110 mg/dL or over). Results: crude U-shaped relationship were observed between the nine HDL-C and blood pressures in both men and women. Logistic regression analysis showed left-to-right inverted J-shaped relationships between HDL-C and odds ratios for HBP (≥140/90 mmHg and/or pharmacotherapy), with lower limits of 90–99 mg/dL in both sexes, which were unchanged after adjusting for confounding factors. However, further adjustment for body mass index and serum triglyceride concentration revealed positive linear associations between HDL-C and HBP, although blunt U-shaped associations remained in nonalcohol drinkers. Conclusion: both low and extremely high HDL-C concentrations are associated with HBP. The former association might be dependent on excess fat mass concomitant with low HDL-C, whereas the latter association may be largely dependent on frequent alcohol consumption.
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影响因子：
3.6
作者：
Huang YQ;Liu XC;Lo K;Liu L;Yu YL;Chen CL;Huang JY;Feng YQ;Zhang B
通讯作者：
Zhang B
影响因子：
2.8
作者：
Kodama, Satoru;Horikawa, Chika;Sone, Hirohito
通讯作者：
Sone, Hirohito
影响因子：
158.5
作者：
Lincoff, A. Michael;Nicholls, Stephen J.;Nissen, Steven E.
通讯作者：
Nissen, Steven E.
胆固醇酯转移蛋白抑制剂治疗血脂异常：系统评价和荟萃分析。
影响因子：
3.7
作者：
Li C;Zhang W;Zhou F;Chen C;Zhou L;Li Y;Liu L;Pei F;Luo H;Hu Z;Cai J;Zeng C
通讯作者：
Zeng C
影响因子：
4.6
作者：
Li, Xintao;Guan, Bo;Sun, Jianhui
通讯作者：
Sun, Jianhui