Adherence to antiretroviral therapy and its determinants in children with human immunodeficiency virus infection:: a multicentre, national study
Adherence to antiretroviral therapy and its determinants in children with human immunodeficiency virus infection:: a multicentre, national study
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DOI：
10.1080/08035250310006737
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发表时间：
2003-01-01
期刊：
影响因子：
3.8
通讯作者：
Guarino, A
中科院分区：
文献类型：
--
作者：
Giacomet, V;Albano, F;Guarino, A
目的：调查感染人类免疫缺陷病毒(HIV)的意大利儿童坚持抗逆转录病毒治疗的比率和决定因素。方法：通过对HIV感染儿童的照顾者进行结构化访谈，进行一项观察性的、横断面的多中心研究。访谈包括访谈前4天内依从性的量化信息。记录儿童的社会人口学、临床和心理社会特征。结果：129名儿童(中位年龄96个月)入选，其中94名接受高效抗逆转录病毒治疗(HAART)。21例(16%)在4d内遗漏了总剂量的5%以上，被认为是未依附的。然而，只有11%的照顾者报告说在正确的时间进行了治疗。不同年龄、不同HIV感染阶段之间差异无统计学意义。意识到自己的艾滋病毒状况的儿童较少遵守。个别药物表现出广泛的依从性，接受HAART的儿童依从性更强。接受养父母治疗的儿童比从亲生父母或亲属那里接受药物治疗的儿童更有依从性。心理而不是临床或社会人口学特征和药物类型是依从性的主要决定因素。
Aim: To investigate rates and determinants of adherence to antiretroviral therapy in Italian children infected with the human immunodeficiency virus (HIV). Methods: An observational, cross-sectional multicentre study was performed through a structured interview with the caregivers of HIV-infected children. The interview included quantitative information on adherence in the 4 d before interview. Sociodemographic, clinical and psychosocial characteristics of children were recorded. Results: 129 children (median age 96 mo) were enrolled, of whom 94 were on highly active antiretroviral therapy (HAART). Twenty-one (16%) omitted more than 5% of total doses in 4 d and were considered non-adherent. However, only 11% of caregivers reported that therapy had been administered at the correct times. No significant difference was found between age and the stage of HIV infection. Children aware of their HIV status were less adherent. Individual drugs showed a broad adherence pattern and children who received HAART were more adherent. Children receiving therapy from foster parents were more adherent than those receiving drugs from biological parents or relatives.Conclusions: Adherence is a major problem in children. Psychological rather than clinical or sociodemographic features and types of drug are major determinants of adherence.