Diagnostic characteristics of different carbohydrate-deficient transferrin methods in the detection of problem drinking:: Effects of liver disease and alcohol consumption
Diagnostic characteristics of different carbohydrate-deficient transferrin methods in the detection of problem drinking:: Effects of liver disease and alcohol consumption
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DOI：
10.1093/alcalc/agg102
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发表时间：
2003-09-01
影响因子：
2.8
通讯作者：
Niemelä, O
中科院分区：
文献类型：
--
作者：
Anttila, P;Järvi, K;Niemelä, O
Aims: Due to methodological heterogeneity, conflicting views have been expressed on the validity of CDT measurements in the detection of alcohol misuse. Methods: We compared the characteristics of the conventional CDTect method and the Axis turbidimetric CDT assays in the assessment of 62 alcoholics, who were either with (n=33) or without (n=29) liver disease, as analysed by combined clinical, laboratory, and morphological indices. Controls were 45 healthy volunteers who were either social drinkers or abstainers. Results: In the total sample of alcoholics, the sensitivity of the %CDT method, which excludes the trisialotransferrin isoform from the measurement, was 63% for men and 46% for women, as compared to 65% and 36% of CDTect, respectively. Both of these methods showed higher sensitivities than the %CDT-TIA method, which reacts with trisialotransferrin (32% and 25%, respectively). The assay specificities were 100% for men and 91% for women with %CDT, and 96% and 87% with the CDTect, respectively. The correlation between the CDTect and %CDT method was higher in men (r=0.86) than in women (r=0.57). The presence of liver disease was found to influence the results of the CDTect method, such that the highest CDT concentrations were observed in patients with mild to moderate liver disease, especially among women, whereas the %CDT method was less sensitive to the effect of liver pathology. The self-reported alcohol consumption from the 4 weeks prior to sampling showed a higher correlation between the %CDT results (r=0.64, P
