Adaptive changes in neuronal synchronization in macaque V4.
Adaptive changes in neuronal synchronization in macaque V4.
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DOI：
10.1523/jneurosci.6227-10.2011
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发表时间：
2011-09-14
期刊：
影响因子：
--
通讯作者：
Dragoi V
中科院分区：
文献类型：
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作者：
Wang Y;Iliescu BF;Ma J;Josić K;Dragoi V
皮质神经元的一个基本特性是表现出适应性变化或可塑性的能力。皮层反应的适应性变化是否伴随着感觉皮层中单个神经元和局部群体活动之间同步性的变化尚不清楚。这个问题很重要，因为同步神经活动被假设在神经元回路中传播信息中发挥重要作用。在这里，我们表明，对固定方向刺激的快速适应（300毫秒）可以调节猕猴视觉皮层（V4区）振荡神经元同步的强度，并影响神经元区分刺激方向微小变化的能力。具体来说，快速适应增加了伽马频带（30-80 Hz）中个体神经元反应与局部群体活动的同步性。与之前关于伽马同步与 V4 放电率增加相关的报道相反，我们发现适应后伽马同步的增加与神经元反应的减少相关。适应后伽玛带同步的增加具有重要的功能，因为它与神经元方向辨别性能的改善相关。因此，单个神经元的尖峰活动与其局部群体之间的自适应同步可以增强用于感觉辨别的时间不敏感、基于速率的编码方案。
A fundamental property of cortical neurons is the capacity to exhibit adaptive changes or plasticity. Whether adaptive changes in cortical responses are accompanied by changes in synchrony between individual neurons and local population activity in sensory cortex is unclear. This issue is important as synchronized neural activity is hypothesized to play an important role in propagating information in neuronal circuits. Here we show that rapid adaptation (300 ms) to a stimulus of fixed orientation modulates the strength of oscillatory neuronal synchronization in macaque visual cortex (area V4) and influences the neurons’ ability to distinguish small changes in stimulus orientation. Specifically, rapid adaptation increases the synchronization of individual neuronal responses with local population activity in the gamma frequency band (30–80 Hz). In contrast to previous reports that gamma synchronization is associated with an increase in firing rates in V4, we found that the post-adaptation increase in gamma synchronization is associated with a decrease in neuronal responses. The increase in gamma-band synchronization after adaptation is functionally significant as it is correlated with an improvement in neuronal orientation discrimination performance. Thus, adaptive synchronization between the spiking activity of individual neurons and their local population can enhance temporally-insensitive, rate-based-coding schemes for sensory discrimination.