Delta power in sleep in relation to neuropsychological performance in healthy subjects and schizophrenia patients
Delta power in sleep in relation to neuropsychological performance in healthy subjects and schizophrenia patients
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DOI：
10.1176/jnp.2006.18.4.529
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发表时间：
2006-09-01
影响因子：
2.9
通讯作者：
Fritzer, Gunther
中科院分区：
文献类型：
--
作者：
Goeder, Robert;Aldenhoff, Josef Bernd;Fritzer, Gunther
睡眠中的Delta功率越来越引起人们的兴趣，因为它与神经心理测试中的清醒表现有关。在精神分裂症患者中，这种联系可能会受到损害，因为睡眠中的德尔塔能量下降和明显的认知缺陷。作者分析了16例接受阿米苏非利稳定治疗的精神分裂症患者和17例健康人的睡眠Delta功率和神经心理表现。在健康受试者中，作者发现清晨在陈述性记忆、程序性学习、注意力和增量能力方面的表现显著正相关，尤其是在额叶通道。作者从精神分裂症患者丘脑皮质和前额叶网络功能障碍的角度来解释这些结果。
Delta power in sleep is of increasing interest because of its association with waking performance in neuropsychological tests. In schizophrenia, this link might be impaired because of a decrease in delta power in sleep and pronounced cognitive deficits. The authors analyzed delta power in sleep and neuropsychological performance in 16 patients with schizophrenia on stable medication with amisulpride and 17 healthy subjects. In healthy subjects, the authors found significant positive correlations between morning performance in declarative memory, procedural learning, and attention and delta power, especially in frontal channels. The authors interpret these results in terms of dysfunctions of thalamocortical and prefrontal networks in schizophrenia.