Regulation of expression of human RNA polymerase II-transcribed snRNA genes.
Regulation of expression of human RNA polymerase II-transcribed snRNA genes.
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DOI：
10.1098/rsob.170073
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发表时间：
2017-06
期刊：
影响因子：
5.8
通讯作者：
Murphy S
中科院分区：
文献类型：
--
作者：
Guiro J;Murphy S
除了蛋白质编码基因外，RNA聚合酶II （pol II）还转录许多非编码RNA的基因，包括小核RNA （sn）基因。snrna是一类重要的非编码rna，其中一些参与pre-mRNA剪接。与蛋白质编码基因相比，人类pol ii转录snRNA基因表达的分子机制尚不清楚，这两种基因类型的表达存在重要差异。在这里，我们回顾了snRNA基因高效转录和转录本共转录3 '端形成所需的DNA特征和蛋白质。
In addition to protein-coding genes, RNA polymerase II (pol II) transcribes numerous genes for non-coding RNAs, including the small-nuclear (sn)RNA genes. snRNAs are an important class of non-coding RNAs, several of which are involved in pre-mRNA splicing. The molecular mechanisms underlying expression of human pol II-transcribed snRNA genes are less well characterized than for protein-coding genes and there are important differences in expression of these two gene types. Here, we review the DNA features and proteins required for efficient transcription of snRNA genes and co-transcriptional 3′ end formation of the transcripts.