Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents?
Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents?
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DOI：
10.1002/pd.2677
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发表时间：
2011-02-01
影响因子：
3
通讯作者：
Bhide, Amar
中科院分区：
文献类型：
--
作者：
Santo, Susana;Mansour, Sahar;Bhide, Amar
目的探讨一系列产前发现的非免疫性积水(NIH)胎儿的病因及结局。研究结果与最新报道进行了比较。方法这是一项回顾研究，回顾了10年间所有妊娠20周后继续妊娠的胎儿NIH。结果从尸检报告、出院总结、与临床医生的沟通或父母的信息中获得。对近10年来有关NIH的所有报道进行文献检索。结果本研究纳入71例胎儿。对40例NIH的病因进行了产前鉴定。NIH最常见的原因是胸部疾病、感染和心血管疾病。71个胎儿中有44个(62%)是活产的。有10例新生儿死亡。在其余34名婴儿中，17名婴儿无病存活。结论本研究中NIH的存活率至少为48%。在56%的病例中，产前确定病因是可能的。那些存活下来的人中，神经发育延迟的风险为3/28(11%)。版权所有(C)2011 John Wiley&Sons，Ltd.
Objective The aim of this study is to outline the aetiology and outcome of a series of fetuses with non-immune hydrops (NIH), detected prenatally. The findings are compared with a comprehensive review of recent reports.Methods This is a retrospective study reviewing all pregnancies complicated by NIH in the fetus and continued after 20 weeks of pregnancy over a period of 10 years. Outcome was obtained from postmortem reports, discharge summaries, communication with the clinicians or information from the parents. A literature search was also performed to identify all reports on NIH in the last 10 years.Results Seventy-one fetuses affected by NIH were included in this study. The aetiology of the NIH was identified prenatally in 40 cases. The most common causes of NIH were thoracic disorders, infections and cardiovascular disorders. Forty-four of the 71 (62%) fetuses were live-born. There were 10 neonatal deaths. Of the remaining 34 babies, 17 infants survived without morbidity.Conclusion The survival rate of NIH is at least 48% in this study. Prenatal identification of the cause is possible in 56% of cases. The risk of neurodevelopmental delay in those that survive is 3 of 28 (11%). Copyright (C) 2011 John Wiley & Sons, Ltd.