Postprandial changes in plasma GH and insulin concentrations, and responses to stimulation with GH-releasing hormone (GHRH) and GHRP-6 in calves around weaning.
Postprandial changes in plasma GH and insulin concentrations, and responses to stimulation with GH-releasing hormone (GHRH) and GHRP-6 in calves around weaning.
复制标题
断奶前后犊牛血浆 GH 和胰岛素浓度的餐后变化，以及对 GHRH 和 GHRP-6 刺激的反应。
DOI：
10.1677/joe.1.05898
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Y. Obara
中科院分区：
文献类型：
--
作者：
K. Katoh;G. Furukawa;K. Kitade;N. Katsumata;Y. Kobayashi;Y. Obara
在3周龄（牛奶喂养）和12周龄（精料和干草喂养）小牛之间比较了GH和胰岛素的血浆浓度的变化，以响应喂养和刺激与GH释放激素（GHRH）或GH释放肽（GHRP-6，内源性GH促分泌素受体的配体）。喂养3周龄的动物的牛奶中的饲料显着增加的基础（喂前）浓度的GH，胰岛素和血浆中的葡萄糖，而喂养的浓缩物和干草在12周龄的动物并没有引起这些性状的显着变化。然而，在动物保持在一个牛奶-脱脂饲料，直到12周龄，餐后血浆GH浓度和AUC（曲线下面积）是没有不同的年龄匹配的断奶组。静脉注射GHRH（0.25 μ g/kg）或GHRP-6（2.5 μ g/kg）显著增加3周龄和12周龄动物的血浆GH浓度，但3周龄动物的GH AUC显著高于12周龄动物。胰岛素浓度是短暂的，但显着增加注射GHRP-6仅在12周龄的动物，AUC是大于12周龄比3周龄的动物。从这些结果中，我们得出结论，餐后血浆GH和胰岛素浓度的水平改变后断奶和老化，和饮食质量或消化-垂体系统的神经内分泌功能的发展可能参与这种改变。
Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves. Feeding of a milk-replacer diet in 3-week-old animals significantly increased the basal (prefeeding) concentrations of GH, insulin and glucose in plasma, whereas feeding of concentrate and hay in 12-week-old animals did not cause a significant change in these traits. However, in the animals maintained on a milk-replacer diet until 12 weeks of age, postprandial plasma GH concentrations and AUC (area under the curve) were not different from those in the age-matched weaned group. The venous injection of either GHRH (0.25 microg/kg) or GHRP-6 (2.5 microg/kg) significantly increased plasma GH concentrations in both 3- and 12-week-old animals, but GH AUC was significantly greater in 3-week-old than in 12-week-old animals. Insulin concentration was transiently but significantly increased by the injection of GHRP-6 only in 12-week-old animals, the AUC being greater in 12-week-old than 3-week-old animals. From these results, we conclude that postprandial levels of plasma GH and insulin concentrations are altered after weaning and by aging, and that the quality of diets or development of the neuroendocrine functions in the digestive-pituitary system may be involved in this alteration.
体外绵羊胎儿和新生儿垂体细胞中 GH 释放因子、生长抑素和胰岛素样生长因子 I 对生长激素 (GH) 分泌的调节。
影响因子：
4.8
作者：
Silverman,BL;Bettendorf,M;Kaplan,SL;Grumbach,MM;Miller,WL
通讯作者：
Miller,WL
猪类胰岛素生长因子系统：处于营养、生长和繁殖的界面。
DOI：
10.1093/jn/128.2.315s
发表时间：
1998
期刊：
The Journal of nutrition
影响因子：
--
作者：
Simmen,FA;Badinga,L;Green,ML;Kwak,I;Song,S;Simmen,RC
通讯作者：
Simmen,RC
绵羊肠道钠/葡萄糖协同转运蛋白 (SGLT1) 的调节与 mRNA 丰度无关。
DOI：
10.1042/bj2910435
发表时间：
1993
期刊：
The Biochemical journal
影响因子：
--
作者：
Lescale-Matys,L;Dyer,J;Scott,D;Freeman,TC;Wright,EM;Shirazi-Beechey,SP
通讯作者：
Shirazi-Beechey,SP