Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition
Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition
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DOI：
10.1148/radiol.2017161127
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发表时间：
2017-08-01
期刊：
影响因子：
19.7
通讯作者：
Hart, Blaine L.
中科院分区：
文献类型：
--
作者：
Strickland, Corinne D.;Eberhardt, Steven C.;Hart, Blaine L.
目的：确定在CCM1常见拉美裔突变携带者中，CT所见的肾上腺钙化是否与家族性脑海绵状畸形(FCCM)相关。材料和方法：这项研究得到了机构审查委员会的批准。作者回顾了38例FCCM患者、38例年龄和性别匹配的对照组和13例散发性、非家族性脑海绵状畸形(CCM)患者的腹部CT扫描。记录钙化的大小、数目、偏侧性及肾上腺的形态特征。FCCM患者的脑部病变计数由磁共振(MR)成像记录。用Fisher精确检验比较FCCM患者、正常对照组和散发性CCM患者肾上腺钙化的发生率。此外，还进行了其他分析，以确定年龄和脑病变数量是否与FCCM患者的肾上腺表现有关。
Purpose: To determine if adrenal calcifications seen at computed tomography (CT) are associated with familial cerebral cavernous malformations (fCCMs) in carriers of the CCM1 Common Hispanic Mutation.Materials and Methods: This study was approved by the institutional review board. The authors retrospectively reviewed abdominal CT scans in 38 patients with fCCM, 38 unaffected age-and sex-matched control subjects, and 13 patients with sporadic, nonfamilial cerebral cavernous malformation (CCM). The size, number, and laterality of calcifications and the morphologic characteristics of the adrenal gland were recorded. Brain lesion count was recorded from brain magnetic resonance (MR) imaging in patients with fCCM. The prevalence of adrenal calcifications in patients with fCCM was compared with that in unaffected control subjects and those with sporadic CCM by using the Fisher exact test. Additional analyses were performed to determine whether age and brain lesion count were associated with adrenal findings in patients with fCCM.Results: Small focal calcifications (SFCs) (