Bacteriophage Diversity
Bacteriophage Diversity
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DOI：
10.21775/9781910190852.07
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Lehman, Susan M.
中科院分区：
文献类型：
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作者：
Lehman, Susan M.
经过100多年的研究，我们对噬菌体多样性的理解已经从单一的，高度适应性的噬菌体物种的假设扩展到对一毫升海水中可能存在的巨大多样性的欣赏。随着研究噬菌体的新工具被开发出来，噬菌体分类学随着时间的推移发生了变化，这一进展是显而易见的。电子显微镜加入了基本的微生物学方法。DNA结构的解决开启了遗传学时代，最终导致了快速、廉价的测序和多方面的“组学”方法。其结果是对噬菌体多样性的日益复杂的理解，从种群水平下降到单个噬菌体-宿主感染的动态。
Over 100 years of research, our understanding of bacteriophage diversity has expanded from the hypothesis of a single, highly adaptable phage species to an appreciation for the tremendous diversity that can exist in a millilitre of seawater. This progression is evident from the way that phage taxonomy has changed over time, as new tools for studying phages were developed. Basic microbiological methods have been joined by electron microscopy. Resolving the structure of DNA ushered in the genetics era that has ultimately led to rapid, inexpensive sequencing and the multi-faceted '-omics' approaches. The result has been an increasingly sophisticated understanding of phage diversity from a population level down to the dynamics of a single phage-host infection.