Heat shock protein 72 (HSPA1B) gene polymorphism and toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children
Heat shock protein 72 (HSPA1B) gene polymorphism and toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children
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DOI：
10.1203/pdr.0b013e318030d1f4
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发表时间：
2007-03-01
影响因子：
3.6
通讯作者：
Reusz, Georg S.
中科院分区：
文献类型：
--
作者：
Karoly, Eva;Fekete, Andrea;Reusz, Georg S.
先天性免疫和尿路反应在尿路感染(UTI)的发生发展中起着核心作用。热休克蛋白(HSP)72和Toll样受体(TLR)4是天然防御机制的关键元件。本研究采用等位基因特异性聚合酶链式反应技术对103例复发性尿路感染患者进行了HSPAIB A(1267)G和TLR4 A(896)G多态的检测。将等位基因患病率与235名健康对照的参考值进行比较。临床数据也进行了统计评估。TLR4896AG基因型和TLR4896G等位基因在尿路感染患者中的患病率也高于对照组(P分别为0.031和0.041)。我们的数据表明HSPAIB(1267)G和TLR4(896)G等位基因的携带者状态与儿童复发性尿路感染的发展之间的关系独立于其他肾脏异常，同时也提出了关于这些多态在日常儿童肾病中的临床和治疗相关性的进一步问题。
Innate immunity and urinary tract response play a central role in the development of urinary tract infection (UTI). Heat shock protein (HSP) 72 and Toll-like receptor (TLR) 4 are among the key elements of innate defence mechanisms. This study assesses the role of HSPAIB A(1267)G and TLR4 A(896)G polymorphisms using allele-specific polymerase chain reaction in 103 patients treated with recurrent UTI. Allelic prevalence was compared with reference values of 235 healthy controls. Clinical data were also statistically evaluated. TLR4 (896)AG genotype and TLR4 (896)G allele had also higher prevalence in UTI patients versus controls (p = 0.031 and 0.041, respectively). Our data indicates a relationship between the carrier status of HSPAIB (1267)G and TLR4 (896)G alleles and the development of recurrent UTI in childhood independently of other renal abnormalities, while raising further questions about the clinical and therapeutic relevance of these polymorphisms in everyday pediatric nephrology.