Ectopic expression of mucins in colorectal cancer metastasis.
Ectopic expression of mucins in colorectal cancer metastasis.
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DOI：
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发表时间：
1991-04
影响因子：
14.5
通讯作者：
T. Irimura;Y. Matsushita;S. Hoff;T. Yamori;S. Nakamori;M. Frazier;G. Giacco;K. Cleary;D. Ota
中科院分区：
文献类型：
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作者：
T. Irimura;Y. Matsushita;S. Hoff;T. Yamori;S. Nakamori;M. Frazier;G. Giacco;K. Cleary;D. Ota
肿瘤转移是恶性细胞的异位生长。在人类结直肠癌中，据推测，在疾病进展到晚期时，原发肿瘤中出现高度恶性和转移性肿瘤细胞并成为主要肿瘤。基于这一假设，通过比较不同临床阶段患者的手术标本，寻找与转移细胞相关的分子。转移潜力增加且预后不良的结直肠癌的特点是器官特异性黏液蛋白决定因子（硫粘蛋白）的缺失，非肠道黏液蛋白的表达增加，黏液蛋白上粘附配体（唾液二聚体Lex抗原）的异位表达。
Cancer metastasis is an ectopic growth of malignant cells. In human colorectal cancer, it is hypothesized that, during the progression of the disease to an advanced stage, highly malignant and metastatic tumor cells arise within primary tumors and become predominant. Based on this hypothesis, molecules associated with metastatic cells have been sought by the comparison of surgical specimens from patients at various clinical stages. Colorectal carcinomas with increased metastatic potential and with poor prognosis have been characterized by a loss of an organ-specific mucin determinant (sulfomucin), by an increased expression of non-intestinal sialomucins, and by an ectopic expression of adhesion ligands (sialyl-dimeric Lex antigens) on mucins.