Signal Transduction at the Single-Cell Level: Approaches to Study the Dynamic Nature of Signaling Networks.
Signal Transduction at the Single-Cell Level: Approaches to Study the Dynamic Nature of Signaling Networks.
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DOI：
10.1016/j.jmb.2016.07.009
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发表时间：
2016-09-25
影响因子：
5.6
通讯作者：
Wollman R
中科院分区：
文献类型：
--
作者：
Handly LN;Yao J;Wollman R
信号转导，或者细胞如何解释和反应外部事件，是细胞功能的一个基本方面。信号转导途径的传统研究涉及在群体水平上绘制细胞信号转导途径。然而，群体平均读数并不能充分阐明单细胞水平上发现的复杂动态和异质反应。观察细胞反应、计算信号通路模型和实验操作细胞的最新技术进步现在使得能够在单细胞水平上研究信号转导。这些研究将使人们能够更深入地了解信号网络的动态性质。
Signal transduction, or how cells interpret and react to external events, is a fundamental aspect of cellular function. Traditional study of signal transduction pathways involves mapping cellular signaling pathways at the population level. However, population averaged readouts do not adequately illuminate the complex dynamics and heterogeneous responses found at the single-cell level. Recent technological advances to observe cellular response, computationally model signaling pathways, and experimentally manipulate cells now enables studying signal transduction at the single-cell level. These studies will enable deeper insights into the dynamic nature of signaling networks.