The basal ganglia and semantic engagement: Potential insights from semantic priming in individuals with subcortical vascular lesions, Parkinson's disease, and cortical lesions
The basal ganglia and semantic engagement: Potential insights from semantic priming in individuals with subcortical vascular lesions, Parkinson's disease, and cortical lesions
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DOI：
10.1017/s1355617703970081
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发表时间：
2003-11-01
影响因子：
2.6
通讯作者：
Copland, D
中科院分区：
文献类型：
--
作者：
Copland, D
通过比较非丘脑皮质下（NS）血管病变、帕金森病（PD）、皮质病变和匹配对照组在语义启动任务上的表现，研究了基底神经节功能障碍对语义处理的影响。在听觉启动-目标对中使用了不均衡的词汇歧义启动，包括4个关键条件;显性相关（例如，银行货币），从属相关（例如，河岸-河流），显性无关（例如，脚钱）和从属无关（例如，蝙蝠河）。参与者使用去不去的反应对目标进行快速词汇决策（词/非词）。当一个短的prime-target interstimulus interval（ISI）为200 ins时，所有组都表现出对显性和从属条件的启动，表明非选择性意义促进和完整的自动词汇处理。差异出现在长ISI（1250毫秒），其中控制和皮质病变的参与者证明了选择性促进的主导意义，而NS和PD组表现出一个长期的非选择性的意义促进。这一发现表明，在语义网络的意义频率的基础上的选择性注意参与有限的赤字，可能涉及影响抑制性语义机制的额叶皮层下系统的干扰。
The impact of basal ganglia dysfunction on semantic processing was investigated by comparing the performance of individuals with nonthalamic subcortical (NS) vascular lesions, Parkinson's disease (PD), cortical lesions, and matched controls on a semantic priming task. Unequibiased lexical ambiguity primes were used in auditory prime-target pairs comprising 4 critical conditions; dominant related (e.g., bank-money), subordinate related (e.g., bank-river), dominant unrelated (e.g.,foot-money) and subordinate unrelated (e.g., bat-river). Participants made speeded lexical decisions (word/nonword) on targets using a go-no-go response. When a short prime-target interstimulus interval (ISI) of 200 ins was employed, all groups demonstrated priming for dominant and subordinate conditions, indicating nonselective meaning facilitation and intact automatic lexical processing. Differences emerged at the long ISI (1250 ms), where control and cortical lesion participants evidenced selective facilitation of the dominant meaning, whereas NS and PD groups demonstrated a protracted period of nonselective meaning facilitation. This finding suggests a circumscribed deficit in the selective attentional engagement of the semantic network on the basis of meaning frequency, possibly implicating a disturbance of frontal-subcortical systems influencing inhibitory semantic mechanisms.