Odor Identification Deficit Predicts Clinical Conversion from Mild Cognitive Impairment to Dementia Due to Alzheimer's Disease
Odor Identification Deficit Predicts Clinical Conversion from Mild Cognitive Impairment to Dementia Due to Alzheimer's Disease
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DOI：
10.1093/arclin/act032
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发表时间：
2013-08-01
影响因子：
2.6
通讯作者：
Rozzini, Luca
中科院分区：
文献类型：
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作者：
Conti, Marta Zaffira;Vicini-Chilovi, Barbara;Rozzini, Luca
本研究的目的是分析受轻度认知障碍（MCI）影响的受试者的嗅觉和认知功能之间的关系，并调查嗅觉缺陷是否可能反映从MCI转换为痴呆的可能性。在这项对MCI门诊患者样本进行的纵向研究中，对88名MCI受试者和46名健康对照受试者进行了CA-SIT识别测试。MCI受试者被分为两组，考虑气味识别性能：40%的正常性能（MCI嗅觉正常），而60%的中度嗅觉缺陷（MCI嗅觉受损）。在2年的随访中，47%的MCI嗅觉受损受试者和11%的MCI嗅觉正常受试者进展为痴呆。在逻辑回归模型中，MMSE评分较低（95%，OR 1.9; IC 1.23-3.01; p = 0.004）和基线时病理性气味识别（95%，OR 5.1; IC 1.16-22.6; p = 0.03）与2年内进展为痴呆独立相关。这项研究证实，气味识别测试可能是有用的，在高风险的设置，以确定患者的风险发展为痴呆症。
The aim of this study was to analyze the relationship between olfactory and cognitive functions in subjects affected by mild cognitive impairment (MCI) and to investigate whether olfactory deficits might reflect the likelihood of conversion from MCI to dementia. In this longitudinal study conducted on a sample of MCI outpatients, CA-SIT Smell Identification Test was administered to 88 MCI subjects and 46 healthy control subjects. MCI subjects have been divided into two groups, considering smell identification performances: 40% had normal performances (MCI olfactory-normal), whereas 60% had a moderate olfaction deficit (MCI olfactory-impaired). At 2-year follow-up, the 47% of MCI olfactory-impaired subjects and the 11% of MCI olfactory-normal subjects progressed to dementia. In a logistic regression model, a lower score in MMSE (95%, OR 1.9; IC 1.23-3.01; p = .004) and a pathological smell identification at baseline (95%, OR 5.1; IC 1.16-22.6; p = .03) were independently associated with the progression to dementia within 2 years. This study confirms that smell identification testing may be useful in high-risk settings to identify patients at risk for developing dementia.