Understanding protein adsorption phenomena at solid surfaces
Understanding protein adsorption phenomena at solid surfaces
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DOI：
10.1016/j.cis.2010.12.007
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发表时间：
2011-02-17
影响因子：
15.6
通讯作者：
Seeger, Stefan
中科院分区：
文献类型：
--
作者：
Rabe, Michael;Verdes, Dorinel;Seeger, Stefan
蛋白质在固体表面的吸附在许多自然过程中起着关键作用，因此在许多研究领域引起了广泛的兴趣。尽管这一领域取得了相当大的进展，但对于如何解释结构重排、协同吸附、超调吸附动力学或蛋白质聚集等常见现象，仍然存在广泛的分歧甚至矛盾的观点。本文综述了蛋白质吸附过程的最新进展和新的研究方向。主要的焦点放在通常假设的机械方面及其转化为数学概念和模型描述。概述了实际接近蛋白质吸附机制领域的相关实验和计算策略及其对当前成功的影响。(c) 2011 Elsevier B.V.版权所有
Protein adsorption at solid surfaces plays a key role in many natural processes and has therefore promoted a widespread interest in many research areas. Despite considerable progress in this field there are still widely differing and even contradictive opinions on how to explain the frequently observed phenomena such as structural rearrangements, cooperative adsorption, overshooting adsorption kinetics, or protein aggregation. In this review recent achievements and new perspectives on protein adsorption processes are comprehensively discussed. The main focus is put on commonly postulated mechanistic aspects and their translation into mathematical concepts and model descriptions. Relevant experimental and computational strategies to practically approach the field of protein adsorption mechanisms and their impact on current successes are outlined. (c) 2011 Elsevier B.V. All rights reserved.