Elevated ghrelin predicts food intake during experimental sleep restriction.
Elevated ghrelin predicts food intake during experimental sleep restriction.
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DOI：
10.1002/oby.21321
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发表时间：
2016-01
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影响因子：
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通讯作者：
Tasali E
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文献类型：
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作者：
Broussard JL;Kilkus JM;Delebecque F;Abraham V;Day A;Whitmore HR;Tasali E
睡眠缩短与肥胖有关，但潜在的机制仍有待阐明。我们评估了在标准化饮食期间，睡眠限制是否会改变食欲调节激素ghrelin、瘦素和胰多肽的24小时曲线，以及这些激素的改变是否可以预测随意喂养期间的食物摄入量。19名健康的瘦人在正常睡眠和睡眠限制下进行了随机交叉研究。在标准化膳食期间收集血液样本24小时。随后，参与者有自由进食的机会（自助餐和小吃），并测量热量摄入。与正常睡眠相比，睡眠限制后Ghrelin水平升高（p<0.01）。总的来说，睡眠限制并没有改变瘦素或胰腺多肽谱。睡眠限制与来自零食的总热量增加328 ± 140 Kcal（p=0.03）相关，主要来自碳水化合物（p=0.02）。睡眠限制期间夜间生长激素释放肽的增加与来自甜食的卡路里消耗量增加相关（r=0.48，p=0.04）。与正常睡眠相比，睡眠限制会显著增加ghrelin水平。生长激素释放肽的增加与更多的卡路里消耗有关。胃饥饿素升高可能是睡眠不足导致食物摄入量增加和肥胖的一种机制。
Sleep curtailment has been linked to obesity, but underlying mechanisms remain to be elucidated. We assessed whether sleep restriction alters 24-hour profiles of appetite-regulating hormones ghrelin, leptin and pancreatic polypeptide during a standardized diet, and whether these hormonal alterations predict food intake during ad libitum feeding. Nineteen healthy, lean men were studied under normal sleep and sleep restriction in a randomized crossover design. Blood samples were collected for 24-hours during standardized meals. Subsequently, participants had an ad libitum feeding opportunity (buffet meals and snacks) and caloric intake was measured. Ghrelin levels were increased after sleep restriction as compared to normal sleep (p<0.01). Overall, sleep restriction did not alter leptin or pancreatic polypeptide profiles. Sleep restriction was associated with an increase in total calories from snacks by 328 ± 140 Kcal (p=0.03), primarily from carbohydrates (p=0.02). The increase in evening ghrelin during sleep restriction was correlated with higher consumption of calories from sweets (r=0.48, p=0.04). Sleep restriction as compared to normal sleep significantly increases ghrelin levels. The increase in ghrelin is associated with more consumption of calories. Elevated ghrelin may be a mechanism by which sleep loss leads to increased food intake and the development of obesity.