A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis
A pilot study of faecal volatile organic compounds in faeces from cholera patients in Bangladesh to determine their utility in disease diagnosis
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DOI：
10.1016/j.trstmh.2009.02.004
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发表时间：
2009-11-01
影响因子：
2.2
通讯作者：
Probert, C. S. J.
中科院分区：
文献类型：
--
作者：
Garner, C. E.;Smith, S.;Probert, C. S. J.
这项试点研究的目的是分析从孟加拉国霍乱患者收集的粪便样本中的挥发性有机化合物，以确定可用于疾病诊断的生物标志物。样本采集自孟加拉国达卡国际腹泻病研究中心的患者以及该机构的健康对照者。挥发性有机化合物采用固相微萃取法从样品上方的顶空气中提取，并采用气相色谱-质谱法分析。在霍乱样本中发现了一种可用于疾病诊断的生物标志物。2009年，爱思唯尔有限公司代表英国皇家热带医学与卫生学会出版。版权所有。
The aim of this pilot study was to analyse the volatile organic compounds in faecal samples collected from cholera patients in Bangladesh to determine biomarkers that could be used for disease diagnosis. Samples were collected from patients at the International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh and also from healthy controls at the same institution. The volatile organic compounds were extracted from the headspace above the sample using solid phase microextraction and analysed using gas chromatography-mass spectrometry. A biomarker was identified in the cholera samples that could be used for disease diagnosis. Crown Copyright (C) 2009 Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved.