A comparative study of apparent diffusion coefficient and intravoxel incoherent motion-derived parameters for the characterization of common solid hepatic tumors
A comparative study of apparent diffusion coefficient and intravoxel incoherent motion-derived parameters for the characterization of common solid hepatic tumors
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DOI：
10.1177/0284185114559426
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发表时间：
2015-12-01
期刊：
影响因子：
1.3
通讯作者：
Guo, Gang
中科院分区：
文献类型：
--
作者：
Zhu, Liuhong;Cheng, Qihua;Guo, Gang
背景资料：目的：比较表观扩散系数（ADC）和体素内非相干运动（IVIM）参数（包括纯扩散系数（D）、灌注系数（D*）和灌注分数（f））在常见肝实体瘤中的表现。材料和方法：12名健康志愿者和43名患者接受了肝脏的自由呼吸弥散加权磁共振成像（DW-MRI），使用8个B值（10-800 s/mm（2））。测量了健康志愿者正常肝组织的12个感兴趣区域（ROI）和49个肝病变（23个肝细胞癌[HCC]，16个血管瘤和10个转移瘤）。计算通过单指数模型获得的常规ADC（（0，500））和ADC（总）以及D、D* 和f。结果：恶性组ADC（0，500）、ADC（total）、D值均显著低于正常组（P < 0.05），而恶性组ADC（0，500）、D值均显著低于正常组（P < 0.05），且ADC值均显著低于正常组（P < 0.05与血管瘤组相比（[1.48 +/- 0.35] x 10（-3）mm（2）/s; [1.35 +/- 0.30] x 10（-3）mm（2）/s; [1.18 +/- 0.33] x 10（-3）mm（2）/s）（[2.74 +/- 1.03] x 10（-3）mm（2）/s; [2.61 +/- 0.81] x 10（-3）mm（2）/s; [1.97 +/- 0.79] x 10（-3）mm（2）/s]。D* 在多重比较中没有差异。对于ROC曲线下面积（AUC-ROC），ADC（总）（0.983）达到最大值，其次是ADC（0，500）（0.967），D（0.837）、f（0.649）和D*（0.599）获得较低值。两种ADC（ADC（总）和ADC（0，500））和D. ADC（total）和ADC（（0，500））的AUC-ROC值差异无统计学意义。结论：ADC在检测恶性组与血管瘤组之间的差异方面显示出优于IVIM的上级诊断性能。
Background: The performance of diffusion-weighted imaging parameters for characterizing hepatic tumors is controversial.Purpose: To compare the performances of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived parameters, including the pure diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f), in the characterization of common solid hepatic tumors.Material and Methods: Twelve healthy volunteers and 43 patients underwent free-breath diffusion-weighted magnetic resonance imaging (DW-MRI) of the liver using eight b values (10-800 s/mm(2)). Twelve regions of interest (ROIs) of normal liver tissue in healthy volunteers and 49 hepatic lesions (23 hepatocellular carcinomas [HCCs], 16 hemangiomas, and 10 metastases) were measured. Conventional ADC((0,500)) and ADC(total) obtained by the mono-exponential model, as well as D, D*, and f were calculated. Student t-tests and receiver operating characteristic (ROC) analysis were also performed.Results: ADC((0,500)), ADC(total), and D were significantly lower in the malignant group ([1.48 +/- 0.35] x 10(-3) mm(2)/s; [1.35 +/- 0.30] x 10(-3) mm(2)/s; [1.18 +/- 0.33] x 10(-3) mm(2)/s) compared to the hemangioma group ([2.74 +/- 1.03] x 10(-3) mm(2)/s; [2.61 +/- 0.81] x 10(-3) mm(2)/s; [1.97 +/- 0.79] x 10(-3) mm(2)/s]. D* did not differ among multiple comparisons. For the area under the ROC curve (AUC-ROC), the maximum value was attained with ADC(total) (0.983) and was closely followed by ADC((0,500)) (0.967), with lower values obtained for D (0.837), f (0.649), and D* (0.599). Statistically significant differences were found between the AUC-ROC of both ADCs (ADC(total) and ADC((0,500))) and D. There was no statistically significant difference between the AUC-ROC of ADC(total) and ADC((0,500)).Conclusion: ADCs showed superior diagnostic performance compared to IVIM-derived parameters in detecting differences between the malignant group and hemangioma group.