Carcinoid-Like Pattern in Sebaceous Neoplasms: Another Distinctive, Previously Unrecognized Pattern in Extraocular Sebaceous Carcinoma and Sebaceoma
Carcinoid-Like Pattern in Sebaceous Neoplasms: Another Distinctive, Previously Unrecognized Pattern in Extraocular Sebaceous Carcinoma and Sebaceoma
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皮脂腺肿瘤中的类癌样模式：眼外皮脂癌和皮脂瘤中另一种独特的、以前未被识别的模式
DOI：
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发表时间：
2005
影响因子：
1.1
通讯作者：
M. Michal
中科院分区：
文献类型：
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作者：
D. Kazakov;H. Kutzner;A. Rütten;P. Mukeňsnabl;M. Michal
该报告强调了类癌样模式，这是皮肤皮脂腺肿瘤中以前未被识别的特征。我们报告了 7 例患有皮脂腺肿瘤的患者，其中肿瘤细胞排列成小梁状和带状图案或形成玫瑰花结/假玫瑰花结。这些病例包括 6 名男性和 1 名女性，诊断时年龄为 43 岁至 87 岁（中位年龄为 59 岁）。所有患者均出现孤立性病变。位置为头皮 (n = 6) 和前臂 (n = 1)。 4 例中肿瘤细胞的类癌样排列是唯一的模式，3 例中还可见所谓的迷路/正弦和/或波纹模式。成熟皮脂细胞形式的皮脂分化从几乎没有到大约10%不等。尽管肿瘤在结构上看起来是良性的，但细胞学异型性的存在使 2 个肿瘤被认定为低级别癌。四个病变代表皮脂瘤，其中 1 例很难在显微镜下区分癌和皮脂瘤。免疫组织化学、组织化学和超微结构未证明神经内分泌分化。对 1 例癌症进行的电子显微镜检查显示少数细胞中有脂质空泡。没有膜结合的神经内分泌颗粒。稀有细胞含有特殊的大日光包裹体。我们得出结论，类癌样模式是指示皮脂腺肿瘤的另一种独特模式。这种模式似乎与波纹和迷宫/正弦模式密切相关，正如我们的案例所证明的那样，其中这些排列有时同时发生。
This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms. We report 7 patients with sebaceous tumors in which neoplastic cells were arranged in a trabecular and ribbon-like pattern or formed rosettes/pseudorosettes. The cases included 6 men and 1 woman, with their ages at the diagnosis ranging from 43 to 87 years (median age, 59). All patients presented with a solitary lesion. Locations were the scalp (n = 6) and forearm (n = 1). The carcinoid-like arrangement of neoplastic cells was the sole pattern in 4 cases, and in 3 cases the so-called labyrinthine/sinusoidal and/or rippled patterns were seen in addition. Sebaceous differentiation in the form of mature sebocytes varied from almost none to approximately 10%. Although the neoplasm appeared benign architecturally, the presence of cytologic atypia qualified 2 tumors as low-grade carcinomas. Four lesions represented sebaceomas, and in 1 case microscopic delineation between a carcinoma and sebaceoma was difficult. No neuroendocrine differentiation was demonstrated immunohistochemically, histochemically, and ultrastructurally. Electron microscopic examination performed in 1 case of carcinoma revealed lipid vacuoles in a minority of cells. There were no membrane-bound neuroendocrine granules. Rare cells contained peculiar large helioid inclusions. We conclude that the carcinoid-like pattern is another distinctive pattern indicative of sebaceous neoplasms. This pattern seems to be closely related to the rippled and labyrinthine/sinusoidal patterns, as exemplified by our cases, in which these arrangements sometimes occurred simultaneously.