The nature of the association between diet and serum lipids in the community: A twin study
The nature of the association between diet and serum lipids in the community: A twin study
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DOI：
10.1037//0278-6133.20.5.341
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发表时间：
2001-09-01
影响因子：
4.2
通讯作者：
Manuck, SB
中科院分区：
文献类型：
--
作者：
McCaffery, JM;Pogue-Geile, MF;Manuck, SB
通常认为饮食是对血清脂质浓度的环境影响。本研究评估了 137 名同卵双胞胎和 67 名异卵年轻双胞胎中的总热量和脂肪摄入量是否可以预测总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL)、高密度脂蛋白胆固醇 (HDL) 和甘油三酯 (TRIG) 浓度的环境因素（与遗传因素相比）。当通过同卵双胞胎之间的相关差异来控制遗传影响时，饮食与 TC、LDL 和 HDL 之间仍然存在显着关联，这表明这些饮食和血清脂质测量因环境原因而相关。双结构方程模型证实了这些结果。总体而言，这些结果为饮食对 TC、LDL 和 HDL 具有环境影响的假设提供了额外的支持。
Diet is commonly thought to be an environmental influence on serum lipid concentrations. This study evaluated whether total caloric and fat intake predict total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TRIG) concentrations for environmental, as compared with genetic, reasons among 137 monozygotic and 67 dizygotic young adult twins. When genetic influences were controlled by correlating differences between monozygotic co-twins, a significant association remained between diet and TC, LDL, and HDL, suggesting that these dietary and serum lipid measures correlate for environmental reasons. Twin structural equation modeling confirmed these results. Overall, these results provide additional support for the hypothesis that diet is an environmental influence on TC, LDL, and HDL.