Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty.
Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty.
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DOI：
10.1093/gerona/glr190
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发表时间：
2012-02
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通讯作者：
S. Eghbalieh;Paraag Chowdhary;A. Muto;Kenneth R Ziegler;F. Kudo;J. Pimiento;Issa Mirmehdi;Lynn Model;Y. Kondo;T. Nishibe;A. Dardik
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作者：
S. Eghbalieh;Paraag Chowdhary;A. Muto;Kenneth R Ziegler;F. Kudo;J. Pimiento;Issa Mirmehdi;Lynn Model;Y. Kondo;T. Nishibe;A. Dardik
颈动脉血管成形术与老年患者的不良事件有关；尚不清楚这是否与炎症轴改变有关。对青年(6月龄)和老年(22~24月龄)Fischer 344大鼠的颈动脉进行球囊损伤。老年大鼠血管腔面积缩小(0.18±0.03比0.24±0.01 mm(2)，p=0.02)，新生内膜增厚(0.15±0.04比0.08±0.03 mm(2)，p=0.006)。老年大鼠循环单核细胞增加(96±21比54±7；p=0.002)，血管成形术后单核细胞数量增加。老年大鼠血管成形术后持续表达单核细胞趋化蛋白-1，而青年大鼠则不表达。老年动脉也表现出血管松弛功能缺陷和eNOS定位异常。老年(≥80岁)重度颈动脉狭窄患者单核细胞数(9.1%±0.4%)高于青年(65-80岁)患者(8.1%±0.3%，P=0.013)。老年大鼠颈动脉血管成形术后出现新生内膜增生，单核细胞数量增加，老年颈动脉狭窄患者循环单核细胞数量增加。这些初步结果可能提示单核细胞在颈动脉血管成形术的反应中起作用。
Carotid angioplasty is associated with adverse events in elderly patients; it is unclear whether this is related to an altered inflammatory axis. The carotid arteries of young (6 months) or aged (22-24 months) Fischer 344 rats were balloon injured. Aged rats had reduced lumen area (0.18 ± 0.03 vs 0.24 ± 0.01 mm(2), p = .02) and increased neointimal thickening (0.15 ± 0.04 vs 0.08 ± 0.03 mm(2), p = .006). Aged rats had increased circulating monocytes (96 ± 21 vs. 54 ± 7; p = .002) as well as increased numbers of monocytes at the post-angioplasty site. Aged rats had sustained monocyte chemotactic protein-1 expression after angioplasty but young rats did not. Aged arteries also exhibited defective vasorelaxation and abnormal eNOS localization. Aged (≥80 years) human patients with high-grade carotid stenosis had increased number of monocytes (9.1% ± 0.4%) compared with younger (65-80 years) patients (8.1% ± 0.3%, p = .013). Aged rats develop neointimal hyperplasia after carotid angioplasty with increased numbers of monocytes, and elderly humans with carotid stenosis have increased numbers of circulating monocytes. These preliminary results may suggest a role for monocytes in the response to carotid angioplasty.