Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination
Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination
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DOI：
10.1111/j.1365-2362.2009.02162.x
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发表时间：
2009-08-01
影响因子：
5.5
通讯作者：
Bamberger, C. M.
中科院分区：
文献类型：
--
作者：
Guth, S.;Theune, U.;Bamberger, C. M.
甲状腺结节在健康人群中的患病率很高：在德国Papillon研究中，使用7个中心点的5 MHz扫描仪对全国9万多人进行超声筛查，发现33%的正常人群存在甲状腺结节。采用更灵敏的13 MHz扫描仪的研究迄今尚未进行。材料和方法635例连续患者（33%女性，67%男性，平均56个中心点7岁）进行预防性健康检查，接受甲状腺超声筛查（Siemens Acuson Anastomy，13 MHz线性扫描仪，B模式和功率模式）和测量基础TSH（促甲状腺激素）值。甲状腺和结节的血管化的大小和程度进行了测定和分析retrospectively.ResultsIn 432的635例患者，甲状腺结节可以检测到随着年龄的增长，发病率增加，在338没有甲状腺肿。女性的平均甲状腺大小为12个中心点3 mL，男性为20个中心点5 mL，与体重密切相关。53%的结节小于5 mm，甲状腺功能障碍的发生率仅为4%。没有癌性病变可以被发现。ConclusionsUsing 13 MHz的技术，我们发现了一个显着较高的患病率甲状腺结节（68%）比Papillon研究（33%）。即使我们的人口比Papillon的年龄大，但在可比年龄组中仍然存在差异。这是由于13 MHz扫描的灵敏度更高。我们的研究强调了碘缺乏的临床意义，并应重新讨论常规补碘。
P>BackgroundThe prevalence of thyroid nodules in a healthy population is high: in the German Papillon study, nationwide ultrasound screening of more than 90 000 people using 7 center dot 5 MHz scanners revealed the presence of thyroid nodules in 33% of the normal population. A study employing more sensitive 13 MHz scanners has not been conducted so far.Materials and methodsSix hundred and thirty-five consecutive patients (33% female, 67% male, mean 56 center dot 7 years) presenting for a preventive health check up underwent ultrasound screening of the thyroid gland (Siemens Acuson Antares, 13 MHz-linear scanner, B-mode and Power mode) and measurement of the basal TSH (thyroid stimulating hormone) value. Size and degree of vascularization of the thyroid gland and of nodules were determined and analysed retrospectively.ResultsIn 432 of 635 patients, thyroid nodules could be detected with an increasing incidence with age, in 338 without goiter. Mean thyroid size was 12 center dot 3 mL for women and 20 center dot 5 mL for men correlating strongly with body weight. Fifty-three percentage of the nodules were smaller than 5 mm. Incidence of thyroid dysfunction was only 4%. No cancerous lesions could be found.ConclusionsUsing the 13 MHz technology, we found a substantially higher prevalence of thyroid nodules (68%) than the Papillon study (33%). Even if our population is older than in Papillon, the difference remains in comparable age groups. This is due to the higher sensitivity of 13 MHz scanning. Our study underlines the clinical significance of iodine deficiency and should renew the discussion on routine iodine supplementation.