Longitudinal changes in hippocampal volumes and cognition in remitted geriatric depressive disorder
Longitudinal changes in hippocampal volumes and cognition in remitted geriatric depressive disorder
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缓解型老年抑郁症海马体积和认知的纵向变化
DOI：
10.1016/j.bbr.2011.10.025
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发表时间：
2012-02-01
影响因子：
2.7
通讯作者：
You, Jiayong
中科院分区：
文献类型：
--
作者：
Hou, Zhenghua;Yuan, Yonggui;You, Jiayong
越来越多的证据表明，抑郁症的发病过程中可能存在海马体积的异常。在这项纵向研究中，我们计算了14名缓解的老年抑郁症（RGD）患者和19名健康参与者在基线和随访时的海马体积。我们发现，在实验A（P = 0.038）和实验B（P = 0.032）中，RGD组的表现有显著改善，右侧海马体积轻度增加。而在RGD患者中，右侧海马体积的变化与符号数字模态测试评分呈正相关（r = 0.675，P = 0.008），左侧海马体积的变化与简易精神状态检查量表评分呈正相关（r = 0.743，P = 0.002）。我们的研究结果表明，海马相关的认知功能障碍和先前解决的海马体积减少可能代表一种状态，而不是抑郁症的永久特征。结果表明，海马体积可能是一个有用的风险标志物转换为阿尔茨海默病的RGD患者。此外，我们的研究表明，有效的抗抑郁药物治疗可能会在一定程度上推迟甚至修改海马的恶化。(C)2011 Elsevier B.V.保留所有权利。
Growing evidences suggest that the abnormality of hippocampal volume may occur in the process of depression. In this longitudinal study, we calculated the hippocampal volume of 14 remitted geriatric depressed (RGD) patients and 19 healthy participants at baseline and follow-up. We found significant improvement of performance in Trail Making Test-A (P = 0.038) and Test-B (P = 0.032), and the right hippocampal volume increased mildly in RGD. However, in RGD patients, positive correlations were seen between the changes in right hippocampal volumes and Symbol Digit Modality Test scores (r = 0.675, P = 0.008), and changes in left hippocampal volumes and Mini-Mental State Examination scores (r = 0.743, P = 0.002). Our findings suggest that hippocampus related cognitive impairment and previously addressed decreased hippocampal volume might represent a state rather than a permanent trait of the depressive disorder. The results suggest that hippocampal volume may be a useful risk marker for conversion to Alzheimer's disease in RGD patients. Additionally, our study indicates that effective antidepressants treatment might postpone and even revise the deterioration of hippocampus to some degree. (C) 2011 Elsevier B.V. All rights reserved.