Basal cortisol is positively correlated to threat vigilance in patients with psychogenic nonepileptic seizures
Basal cortisol is positively correlated to threat vigilance in patients with psychogenic nonepileptic seizures
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DOI：
10.1016/j.yebeh.2009.09.006
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发表时间：
2009-11-01
影响因子：
2.6
通讯作者：
Roelofs, Karin
中科院分区：
文献类型：
--
作者：
Bakvis, Patricia;Spinhoven, Philip;Roelofs, Karin
先前的研究提供了证据，对威胁刺激的警觉性注意偏差和增加基础昼夜皮质醇水平的心因性非癫痫发作（PNES）患者。由于皮质醇水平可能是威胁警惕的预测，我们重新分析了以前的数据，在19个未经药物治疗的PNES患者的威胁警惕，发现基线皮质醇水平和注意力偏差得分之间的正相关性的威胁刺激（r = 0.49，P = 0.035）。在健康对照组（n = 20）或癫痫发作患者（n = 17）中没有这种关系。这些发现提供了第一个证据，将内分泌应激市场与PNES中威胁敏感性增加联系起来，并支持PNES的新的综合心理神经生物学模型。(C)2009 Elsevier Inc. All rights reserved.
Previous studies have provided evidence for a vigilant attentional bias toward threat stimuli and increased basal diurnal cortisol levels in patients with psychogenic nonepileptic seizures (PNES). Because cortisol levels may be predictive of threat vigilance, we reanalyzed previous data on threat vigilance in 19 Unmedicated patients with PNES and found a positive correlation between baseline cortisol levels and attentional bias scores for threat stimuli (r = 0.49, P = 0.035). There was no such relationship in healthy matched controls (n = 20) or in patients with epileptic seizures (n = 17). These findings provide the first evidence linking an endocrine stress market to increased threat sensitivity in PNES and support new integrated psychoneurobiological models of PNES. (C) 2009 Elsevier Inc. All rights reserved.