From funny current to HCN channels: 20 years of excitation
From funny current to HCN channels: 20 years of excitation
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DOI：
10.1152/physiologyonline.2002.17.1.32
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发表时间：
2002-02-01
期刊：
影响因子：
--
通讯作者：
DiFrancesco, D
中科院分区：
文献类型：
--
作者：
Accili, EA;Proenza, C;DiFrancesco, D
“有趣的”(起搏器)电流具有不同寻常的特征，包括对超极化的激活，对K+和Na+的通透性，内部cAMP的调制，以及微小的单通道电导。在心肌细胞和神经元中，起搏通道控制重复的活动和兴奋性。最近HCN亚基的克隆为搞笑通道特性的分子基础提供了新的见解。
The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K+ and Na+, modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.