Circulating adhesion molecules and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis
Circulating adhesion molecules and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1183/13993003.00295-2019
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发表时间：
2019-09-01
影响因子：
24.3
通讯作者：
Podolanczuk, Anna J.
中科院分区：
文献类型：
--
作者：
McGroder, Claire F.;Aaron, Carrie P.;Podolanczuk, Anna J.
粘附分子可能有助于间质性肺疾病（ILD）的发展，并已被提议作为特发性肺纤维化的预后生物标志物。我们的目的是确定是否循环粘附分子可溶性细胞内粘附分子（sICAM）-1，可溶性血管细胞粘附分子（sVCAM）-1和P-选择素与亚临床ILD在社区居住adultes.The动脉粥样硬化的多种族研究招募男性和女性年龄45-84岁，从六个社区在美国在2000-2002年。高衰减区域定义为心脏计算机断层扫描（CT）上衰减为-600--250 HU的成像肺体积百分比。在全肺CT上目视评估间质性肺异常。对一部分个体进行肺量测定。在完全校正的分析中，较高水平的sICAM-1、sVCAM-1和P-选择素与较大的高衰减区域相关（分别为2.94%，95%CI 1.80-4.07%; 1.24%，95%CI 0.14-2.35%;和1.58%，95%CI 0.92- 2.23%），ILD住院率更高（HR分别为1.36，95% CI 1.03-1.80; 1.40，95% CI 1.07-1.85;和2.03，95% CI 1.16-3.5）。sICAM-1与间质性肺异常的患病率较高相关（OR 1.39，95%CI 1.13-1.71）。sICAM-1和P-选择素与较低的用力肺活量相关（分别为44 mL，95% CI 12-76 mL和29 mL，95% CI 8-49 mL）。sVCAM-1和P-选择素与ILD死亡风险增加相关（HR分别为2.15，95%CI 1.26-3.64和3.61，95%CI 1.54-8.46）。循环sICAM-1、sVCAM-1和P-选择素水平升高与亚临床ILD的CT和肺功能测定独立相关，社区居住成人中裁定的ILD事件发生率增加。
Adhesion molecules may contribute to the development of interstitial lung disease (ILD) and have been proposed as prognostic biomarkers in idiopathic pulmonary fibrosis. Our objective was to determine whether the circulating adhesion molecules soluble intracellular adhesion molecule (sICAM)-1, soluble vascular cell adhesion molecule (sVCAM)-1 and P-selectin are associated with subclinical ILD in community-dwelling adults.The Multi-Ethnic Study of Atherosclerosis enrolled males and females aged 45-84 years from six communities in the United States in 2000-2002. High attenuation areas were defined as the percentage of imaged lung volume with attenuation -600--250 HU on cardiac computed tomography (CT). Interstitial lung abnormalities were visually assessed on full-lung CT. Spirometry was performed on a subset of individuals. ILD hospitalisations and deaths were adjudicated.In fully adjusted analyses, higher levels of sICAM-1, sVCAM-1 and P-selectin were associated with greater high attenuation areas (2.94%, 95% CI 1.80-4.07%; 1.24%, 95% CI 0.14-2.35%; and 1.58%, 95% CI 0.92-2.23%, respectively), and greater rate of ILD hospitalisations (HR 1.36, 95% CI 1.03-1.80; 1.40, 95% CI 1.07-1.85; and 2.03, 95% CI 1.16-3.5, respectively). sICAM-1 was associated with greater prevalence of interstitial lung abnormalities (OR 1.39, 95% CI 1.13-1.71). sICAM-1 and P-selectin were associated with lower forced vital capacity (44 mL, 95% CI 12-76 mL and 29 mL, 95% CI 8-49 mL, respectively). sVCAM-1 and P-selectin were associated with increased risk of ILD death (HR 2.15, 95% CI 1.26-3.64 and 3.61, 95% CI 1.54-8.46, respectively).Higher levels of circulating sICAM-1, sVCAM-1 and P-selectin are independently associated with CT and spirometric measures of subclinical ILD, and increased rate of adjudicated ILD events among community-dwelling adults.